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All Journal Indonesian Journal of Cancer Molecular and Cellular Biomedical Sciences (MCBS) Journal Of Widya Medika Junior Indonesian Journal of Cancer Jurnal Widya Medika
Sindrawati, Sindrawati
Department Of Pathology Anatomy Faculty Of Medicine, Widya Mandala Surabaya Catholic University
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Hubungan Faktor Usia dengan Grading Histopatologi, Status Reseptor Hormonal, dan Ekspresi HER-2/neu pada Penderita Karsinoma Payudara di Rumah Sakit Onkologi Surabaya OCTOVIANUS, JACOBUS; -, SINDRAWATI; DJATMIKO, ARIO
Indonesian Journal of Cancer Vol 6, No 1 (2012): Jan - Mar 2012
Publisher : "Dharmais" Cancer Center Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.115 KB)

Abstract

Usia merupakan salah satu faktor prognostik yang penting pada karsinoma payudara. Tujuan: menilai hubungan antara faktor usia dengan faktor yang berkaitan dengan prognosis dan faktor prediksi, yaitu status reseptor hormonal, ekspresi HER-2/neu, dan grading histopatologi pada pasien yang datang ke Rumah Sakit Onkologi Surabaya (RSOS). Metode: penelitian retrospektif dengan mencatat data rekam medis penderita karsinoma payudara baru di RS Onkologi Surabaya, sejak Januari 2007 sampai Desember 2010. Data yang dicatat adalah usia, grading histopatologi, status reseptor hormonal, dan ekspresi HER-2/neu.Hasil: di antara 1.426 penderita baru yang datang di RSOS sejak Januari 2007 sampai Desember 2010, terdapat 844 kasus yang dilakukan pemeriksaan histopatologi dan imunohistokimia untuk status reseptor hormonal ER/PR dan ekspresi HER-2/neu. Didapatkan angka kejadian terbanyak pada rentang usia 45-49 tahun yaitu 160 penderita (19%). Prosentase tertinggi dari status ER + pada rentang usia 40-44 tahun (73,8%); ER- pada usia <35 tahun (45,5%); PR + pada usia 40-44 tahun (65,9%); PR – pada usia 60-64 tahun (54,1%); overekspresi HER-2/neu pada usia 55-59 tahun (36,4%); dan grading histopatologi tinggi pada usia <35 tahun (77,3%). ER+/PR+ pada usia 45-49 (19,6%) dan ER-/PR+ pada usia 35-39 tahun (42,8%). Dari hasil analisis statistik tidak didapat hubungan yang signifikan antara usia dengan faktor biologi tumor, yaitu status ER/PR, HER-2/neu, dan grading histopatologi (p>0,01). Kesimpulan: tidak didapat hubungan yang signifikan antara usia dengan faktor biologi tumor, yaitu status ER/PR, HER-2/neu, dan grading histopatologi.Kata kunci: karsinoma payudara, usia, reseptor hormonal, grading histopathologi, HER-2/neu
Hubungan Overekspresi HER-2/neu dengan Status Reseptor Hormonal dan Grading Histopatologi pada Penderita Karsinoma Payudara di RS Onkologi Surabaya OCTOVIANUS, JACOBUS; -, SINDRAWATI; DJATMIKO, ARIO
Indonesian Journal of Cancer Vol 6, No 3 (2012): Jul - Sep 2012
Publisher : "Dharmais" Cancer Center Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.115 KB)

Abstract

Pendahuluan: Overekspresi HER-2/neu merupakan salah satu faktor prognostik dan faktor prediktif yang penting pada karsinoma payudara. Tujuan: menilai hubungan antara overekspresi HER-2/neu dengan faktor yang berkaitan dengan prognosis dan faktor prediksi, yaitu status Reseptor Hormonal dan Grading Histopatologi pada pasien yang datang ke Rumah Sakit Onkologi Surabaya (RSOS). Metode: penelitian retrospektif dengan mencatat data rekam medis penderita karsinoma payudara baru di RS Onkologi Surabaya, sejak Januari 2007 sampai Desember 2010. Data yang dicatat adalah ekspresi HER-2/neu, grading histopatologi, dan status reseptor hormonal.Hasil: di antara 1.426 penderita baru yang datang di RSOS sejak Januari 2007 sampai Desember 2010, terdapat 844 kasus yang dilakukan pemeriksaan histopatologi dan imunohistokimia untuk status reseptor hormonal ER/PR, dan ekspresi HER-2/neu. Overekspresi dari HER-2/neu didapatkan pada 216 penderita (25,6%). Didapatkan prosentase tertinggi kejadian overekspresi HER-2/neu pada rentang usia 55-59 tahun (36,4%), prosentase tertinggi pada status ER– (37,1%), PR- (33,7%), dan grading histopatologi yang tinggi (34,6%). Dari hasil analisis statistik didapatkan hubungan yang signifikan antara overekspresi HER-2/neu dengan status ER/PR dan grading histopatologi (p<0,01).Kesimpulan: didapatkan hubungan yang signifikan antara overekspresi HER-2/neu dengan faktor biologi tumor yaitu status ER/PR, grading histopatologi.Kata Kunci: karsinoma payudara, HER-2/neu, usia, reseptor hormonal, grading histopatologi.
DIFFERENCES OF MASS AND DIAMETER MUSCLE RATTUS NORVEGICUS IN GIVING KETOGENIC DIETS AND EXERCISE Danika, Andri; Dewi, Dewa AL; Sindrawati, Sindrawati
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 3, No 3 (2021): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v3i3.3343

Abstract

Introduction: Saturated ketogenic diet without exercise can lead to muscle mass decrease and disturb body metabolism. Therefore, the researcher is interested in discovering the differences between a saturated and unsaturated ketogenic diet with exercise to muscle mass and diameter. Purpose: This study aimed to analyze the difference in muscle mass and diameter of Rattus norvegicus, which were given a ketogenic diet and exercise. Method: This experimental research used Rattus norvegicus that had been adapted for two weeks. Rats are divided into five groups; control (K), a saturated ketogenic diet (P1), a saturated ketogenic diet with exercise (P2), an unsaturated ketogenic diet (P3), and anunsaturated ketogenic diet with exercise (P4). Upright running wheel exercise was given to the group with exercise for 10 minutes daily. The ketogenic diet was given with oral gavage. Muscle mass was examined in the second and fourth weeks. Muscle diameter was examined before treatment, second week, and fourth week. Results: There are differences in mass and diameter muscle Rattus norvegicus that givenketogenic diet and exercise (p=0,000). In second week, there are significant increase inmuscle diameter for saturated ketogenic diet without exercise (P1(p=0,000)) and significantdecrease in muscle diameter for three other group (P2(p=0,000), P3(p=0,001), P4(p=0,000)). In the fourth week, there is a significant increase in muscle diameter for an unsaturated ketogenic diet with exercise (P4). Conclusion: An unsaturated ketogenic diet with exercise could increase the mass anddiameter of quadriceps muscle at the end of this research. 
ANTIBACTERIAL TEST OF SQUEEZED WATER OF KATUK LEAF ON STREPTOCOCCUS PYOGENES Novitayanti, Ni Putu S; Rahayu, Titien; Sindrawati, Sindrawati
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 4, No 1 (2022): January
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v4i1.3576

Abstract

Background: Many infectious diseases still can be found in developing countries, including Indonesia. The common type of infection is upper respiratory tract infection (URTI) in which one of the diseases is pharyngitis. About 5% - 40% of pharyngitis cases are caused by Streptococcus pyogenes. One of the treatments for bacterial infection is antibiotics, but the increasing number of antibiotic resistance causes the need to find other alternatives such as herbal plants for the treatment. The community of Bali, particularly in Singaraja, often consume the squeezed water of Katuk leaf (Sauropus androgynus (L.) Merr) to treat pharyngitis.Objectives: This study aims to determine the antibacterial effect of squeezed water of Katuk leaf on Streptococcus pyogenes by measuring the value of the minimum inhibitory concentration (MIC) and the value of the minimum bactericidal concentration (MBC).Methods: The squeezed water of Katuk leaf was obtained through the squeezing method. The antibacterial activity test used the microdilution method of 96 well plates, then the absorbance value was read using a spectrophotometer to determine the MIC value, and streaking was performed to the blood agar strengthened by the results of the spectrophotometric readings to determine the value of MBC.Results: The results showed that the 300 grams of squeezed water of Katuk leaf had MIC values at a concentration of 10% and MBC values at a concentration of 20%.Conclusion: It can be concluded that the squeezed water of Katuk leaf has an antibacterial effect on Streptococcus pyogenes.Keywords: Antibacterial, Sauropus androgynus (L.) Merr, Streptococcus pyogenes
A Comparison of Osteoblast Cell Proliferation and Osteocalcin Expression in Cuttlefish Bone and Bovine Bone Xenograft Komang Agung Irianto; Ameria Pribadi; Ilham Abdullah Irsyam; Yudhistira Pradnyan Kloping; Oen Sindrawati
Molecular and Cellular Biomedical Sciences Vol 3, No 2 (2019)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (5757.072 KB) | DOI: 10.21705/mcbs.v3i2.58

Abstract

Background: Cuttlefish bone Xenograft, calcium phosphate (CaP)-based biomaterial graft, offers an alternative and has been accepted for osteoconductive and probable osteo-inductive attributes. This study aims to compare the bone healing potential between the bovine-derived (BHA) and cuttlefish bone-derived (CHA).Materials and Methods: The study compared osteoblast cell proliferation of 27 New Zealand rabbits in 2.5 mm bone defect made in the femoral bone. The samples were divided into three groups, which were control, BHA and CHA group. The chemical and physical characteristics of BHA and CHA were determined for the content of hydroxyapatite by FourierTransform Infrared Spectroscopy (FTIR) and X-Ray Diffraction (XRD), then tested by Scanning Electron Microscopy (SEM) to evaluate the porosity. In the end of the second week, histopathologic and immunohistochemistry examinations were performed to evaluate the amount of osteoblast and osteocalcin expression.Results: The FTIR, XRD and SEM analysis showed both BHA and CHA samples were hydroxyapatite according to Joint Committee on Powder Diffraction Standards (JCPDS). The CHA was significantly higher (297.22±19.772) compared to BHA (258.22±30.926) and control (131.67±34.213). Osteocalcin expression in CHA (7.82±2.230) compared to BHA (6.09±3.724) and control (4.07±3.606), was not significant (p>0.05). Conclusion: CHA group has the highest osteoblast cell proliferation and osteocalcin expression, meaning has a good potential as future source of bone graft.Keywords: cuttlefish bone, bovine, bone graft, osteoblast cell
Hubungan Overekspresi HER-2/neu dengan Status Reseptor Hormonal dan Grading Histopatologi pada Penderita Karsinoma Payudara di RS Onkologi Surabaya JACOBUS OCTOVIANUS; SINDRAWATI -; ARIO DJATMIKO
Indonesian Journal of Cancer Vol 6, No 3 (2012): Jul - Sep 2012
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v6i3.204

Abstract

Pendahuluan: Overekspresi HER-2/neu merupakan salah satu faktor prognostik dan faktor prediktif yang penting pada karsinoma payudara. Tujuan: menilai hubungan antara overekspresi HER-2/neu dengan faktor yang berkaitan dengan prognosis dan faktor prediksi, yaitu status Reseptor Hormonal dan Grading Histopatologi pada pasien yang datang ke Rumah Sakit Onkologi Surabaya (RSOS). Metode: penelitian retrospektif dengan mencatat data rekam medis penderita karsinoma payudara baru di RS Onkologi Surabaya, sejak Januari 2007 sampai Desember 2010. Data yang dicatat adalah ekspresi HER-2/neu, grading histopatologi, dan status reseptor hormonal.Hasil: di antara 1.426 penderita baru yang datang di RSOS sejak Januari 2007 sampai Desember 2010, terdapat 844 kasus yang dilakukan pemeriksaan histopatologi dan imunohistokimia untuk status reseptor hormonal ER/PR, dan ekspresi HER-2/neu. Overekspresi dari HER-2/neu didapatkan pada 216 penderita (25,6%). Didapatkan prosentase tertinggi kejadian overekspresi HER-2/neu pada rentang usia 55-59 tahun (36,4%), prosentase tertinggi pada status ER (37,1%), PR- (33,7%), dan grading histopatologi yang tinggi (34,6%). Dari hasil analisis statistik didapatkan hubungan yang signifikan antara overekspresi HER-2/neu dengan status ER/PR dan grading histopatologi (p<0,01).Kesimpulan: didapatkan hubungan yang signifikan antara overekspresi HER-2/neu dengan faktor biologi tumor yaitu status ER/PR, grading histopatologi.Kata Kunci: karsinoma payudara, HER-2/neu, usia, reseptor hormonal, grading histopatologi.
THE RELATIONSHIP BETWEEN THE LEVEL OF ANXIETY AND THE INCIDENCE OF DYSPEPSIA SYNDROME AMONG THE STUDENTS OF THE FACULTY OF MEDICINE AT WIDYA MANDALA CATHOLIC UNIVERSITY SURABAYA Fellicia Stephanie Atmajaya; Rossy Sintya Marthasari; Sindrawati .
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 5, No 1 (2023): January
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v5i1.4417

Abstract

Background: Students’ anxiety results from multiple demands placed on them as medical students. Anxiety affects the body's functional systems, including the gastrointestinal system. Dyspepsia syndrome is one of the common symptoms.Objective: To determine whether there is a relationship between anxiety levels and dyspepsia syndrome among students at Widya Mandala Catholic University of Surabaya’s Medical Faculty.Methods: This research is an observational analytic study with a cross-sectional research design. The subjects are obtained using purposive sampling methods from the forces of 2018, 2019, 2020, and 2021. This research uses HARS questionnaires to measure anxiety levels and Rome III criteria to measure dyspepsia syndrome. Statistical analysis is performed by using Pearson Chi-Square.Result: Anxiety levels have a strong, substantial correlation with the incidence rate of dyspepsia syndrome (p=0.000). It is found that there are 4 out of 17 students (23.53%) with mild anxiety have dyspepsia syndrome, 44 out of 55 students (80%) with mild–moderate anxiety have dyspepsia syndrome, and 7 out of 8 students (87.5%) with moderate–severe anxiety have dyspepsia syndrome.Conclusion: There is a significant relationship with a positive correlation, so it can be concluded that if the level of anxiety is higher, the greater the prevalence of dyspepsia syndrome.
ASSOCIATION BETWEEN DIABETES MELLITUS AND OCULAR ANTERIOR SEGMENT MANIFESTATIONS IN COVID-19 PATIENTS Ranita Ivana Cahyadi; Titiek Ernawati; Sindrawati ,
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 5, No 1 (2023): January
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v5i1.4432

Abstract

Background: COVID-19 is an acute respiratory disease caused by the infection of SARS-CoV-2, which was also found to have ocular manifestations. In the previous study, SARS-CoV-2 was found in patients' conjunctival swabs and tear specimens. The SARS-CoV-2 binding sites were found on the conjunctiva and cornea of the eye. Diabetes mellitus is one of the most common comorbidities found in COVID-19 patients, at the same time, hyperglycemia in diabetes mellitus increases the risk of eye infections. This study aims to determine the association between diabetes mellitus and anterior segment ocular manifestations in COVID-19 patients.Methods: This research is an observational analytic cross-sectional study. Anterior segment ocular manifestations data were collected by patient-reported questionnaire due to high infection risk.Results: In the total of 169 COVID-19 patients in this study, 35 patients (20,7%) experienced anterior segment ocular manifestations, 50 patients (29,6%) had diabetes mellitus, and 12 patients (7,1%) experienced both. The most common ocular manifestations experienced were watery eyes (34,3%), red eyes (20,0%), and blurred vision (20,0%), as well as other complaints in the form of discharge from the eyes, itching, burning, foreign body sensation, pain, and glare at the light. While 12 of 50 diabetes mellitus patients (24%) had anterior segment ocular manifestations, 23 of 119 patients without diabetes mellitus (19.32%) experienced similar conditions. The results of data analysis with Chi-Square (p≥0.05) showed no significant association.Conclusions: There is no association between diabetes mellitus and anterior segment ocular manifestations in COVID-19 patients.
DIFFERENCE OF BREAST CANCER ESTROGEN RECEPTOR (ER) BETWEEN OBESE PRE-MENOPAUSE WOMEN AND OBESE POST-MENOPAUSE WOMEN Viqi Vincentius Julio; Sindrawati Sindrawati; Fransiscus Arifin
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 5, No 3 (2023): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v5i3.4853

Abstract

Background: One of the risk of breast cancer is Obesity (BMI > 23Kg/m2) related to estrogen production between pre-menopause and post-menopause.Aim: To investigate the difference of breast cancer estrogen receptor (ER) in obese women based on menopausal status.Methods: This study was retrospective cross-sectional from secondary data (Medical Records) from Poliklinik Onkologi Satu Atap (POSA) RSUD Dr. Soetomo (ICD-10 C50) from 2013-2017 with inclusion criteria was BMI >23Kg/m2. Data were analyzed using Chi-Square.  Results: There were 138 patient medical records collected which is 63 were obese pre-menopause and 75 were obese post-menopause. There were statistically a significant difference (p<0,05) based on Chi square test of breast cancer estrogen receptor for obese post-menopause women (66,7%) to obese pre-menopause (39,7%). Obese post-menopause women have 1,68 times greater risk factor to become estrogen receptor positive (ER+) compared to obese pre-menopause women. (PR = 1,68; 95% CI = 1,191-2,370)  Conclusion : There is a significant difference of breast cancer estrogen receptor in obese post-menopause women more frequent than obese pre-menopause women.
The Role Of Rose (Rapid Onsite Evaluation) On Spinal Lesion Surgery Decision . Sindrawati; Komang Agung; Carlos Binti; Anggita Dewi
JURNAL WIDYA MEDIKA Vol. 5 No. 1 (2019)
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v5i1.2000

Abstract

Introduction: Exposure and instrumentation of the spine must be meticulous and thorough regardless the techniques and approach selected. Management of the whole surgery process should be decided based on the best available evidence whenever possible. ROSE (Rapid Onsite Evaluation) cytology wrap up the surgical decision. Case Description: Fifteen cases comprise of lytic lesions and/or single pathological fractures of the corpus vertebrae will be presented and discuss as to how the surgical techniques and approaches are assisted by ROSE. ROSE cytology was performed in the operating theater during the surgery. Samples were taken after exposure of the minimal lesion using (18–21) G trocar needle or under fluoroscopy guided. Direct smear, air dried fixation, and Diff Quik staining would take about 10 minutes. Pathologist evaluated the specimen and provided the result in about 20 minutes. The overall 30 minutes allowed surgeon to prepare the further steps. Results would be malignant or benign without pursuing further detail diagnostic. Benign results should be categorized as infection, suspicious of granulomatic tuberculosis, or normal host population cells. The cases outcome were 8 normal host population cells advanced for vertebroplasty to fill the porotic bone. Three spondylitis tuberculosis were debrided without unnecessary instrumentation, and four malignant processes were assured to have enough samples for immunohistochemistry evaluation afterward. All ROSE cytology was confirmed accordingly by the histopathology result afterward. Conclusion: ROSE is easy and offers accurate sampling from the lesion itself. It is quick, therefore during surgery surgeon could decide the best management for the patient.
Co-Authors Ameria Pribadi Anggita Dewi ARIO DJATMIKO ARIO DJATMIKO, ARIO Carlos Binti Danika, Andri Dewi, Dewa AL Fellicia Stephanie Atmajaya Fransiscus Arifin Ilham Abdullah Irsyam JACOBUS OCTOVIANUS JACOBUS OCTOVIANUS, JACOBUS Komang Agung Nia Sumiati Novitayanti, Ni Putu S Rahayu, Titien Ranita Ivana Cahyadi Rd. Ratih Hanawidjaya Rezky Afiahtul Barokah Rossy Sintya Marthasari Titiek Ernawati Viqi Vincentius Julio Yudhistira Pradnyan Kloping