Thiamine pharmaconutrition in sepsis: current evidence on safety and efficacy

Gil Hardy (Ipanema Research Trust)
William Manzanares (Universida de la Republica)

World Nutrition Journal
Vol. 7 No. S1 (2023): Selected conference proceedings of the Nutri Symposium 2023

Sepsis is a life-threatening condition characterized by multiorgan dysfunction due to an exaggerated host response to infection associated with a homeostatic failure. Sepsis is also characterized by low thiamine levels, which are associated with illness severity, hyperlactatemia, and poor clinical outcomes. However, caution is needed with interpretation of thiamine blood concentration in critically ill patients.