Hydroxyapatite (HA) is widely used types of biomaterials for bone implants, surgery hard tissue and bone regeneration. The purpose of this research was to determine the effect of Ca/Pratio and pH on the synthesis of hydroxyapatite from sea shells with a low temperature hydrothermal method. CaO powder produced through calcination process of sea shells at atemperature of 1000°C for 24 hours. Then CaO powder as much as 45.91 grams dissolved in 600 ml of water and NH4H2PO4 added with ratio Ca/P 0.67, 1.67 and 2.67 and pH adjusted with variation 4, 6 and 9, then heated at 90°C until form a pasta. The pasta is then dried in the oven at 120°C and calcined at a temperature of 900°C for 1 hour. The results showed that increasing the ratio Ca/P and pH causes the diameter of HA crystals formed smaller with diameter at ratio Ca/P 2,67 and pH 9 was 52,32 nm. FTIR analysis showed peaks of PO4 3- and OH- that means the hydroxyapatite is formed. HA at ratio Ca/P 2,67 and pH 9 had the biggest %yield that was 77,73%.Keywords: Hydrothermal, Hydroxyapatite, Sea shells.
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