PERANAN NEUROHORMONAL DALAM NEUROINFLAMASI PADA STROKE ISKEMIK AKUT

Felicia Theddy (Program Studi Pendidikan Dokter,, Fakultas Kedokteran, Universitas Mataram, Indonesia)
Fadila Olivia (Program Studi Pendidikan Dokter,, Fakultas Kedokteran, Universitas Mataram, Indonesia)
Sang Ayu Nyoman Putri Pradnyasari (Program Studi Pendidikan Dokter,, Fakultas Kedokteran, Universitas Mataram, Indonesia)
Ilsa Hunaifi (Staf Pengajar Bagian Neurologi, Fakultas Kedokteran Universitas Mataram, Indonesia)

Jurnal Inovasi Pendidikan dan Sains
Vol 3 No 3 (2022): December

Stroke is the second most common cause of death and the third most common cause of disability in the world. Globally, 68% suffer from ischemic stroke. Post-ischemic stroke occurs a neuroinflammatory process which is a natural response of the immune system to tissue ischemia. The inflammatory process develops into three phases, namely the acute phase which begins shortly after the ischemic stroke, the subacute phase which begins several days after the ischemic stroke, and the final phase of astrocyte and microglia recovery. Neuroinflammation is a complex process involving inflammatory cells, inflammatory mediators, and hormones. Hormones that play a role in the neuroinflammatory process either increase or decrease the inflammatory response, namely estrogen, progesterone, testosterone, oxytocin, glucocorticoids, and cortisol.