Aloe vera Gel Ameliorates Fat-Rich and High Fructose (FRHF) Diet-Induced Pancreatic and Splenic Damage in Mice

Nathan Isaac Dibal (University of Maiduguri)
Zainab Muhammad Goni (University of Maiduguri)
Martha Orendu Oche Attah (Cyprus International University)
Umar Imam (University of Maiduguri)
Muhammad Abdullahi (University of Maiduguri)
Muzammil Bashir (University of Maiduguri)
Usman Adam (University of Maiduguri)
Fatima Aisami (University of Maiduguri)
Mohammed Shuwa (University of Maiduguri)
Sunday Joseph Manye (University of Maiduguri)
Madu Nom Gadzama (University of Maiduguri)
Musa Samaila Chiroma (Newcastle University Medicine Malaysia)
Helga Bedan Ishaya (University of Maiduguri)

Borneo Journal of Pharmacy
Vol. 6 No. 3 (2023): Borneo Journal of Pharmacy

High-fat diet alone or in combination with high fructose has been known to induce diabetes, obesity, hypertension, and immune dysfunction. The study evaluates the role of Aloe vera in fat-rich and high fructose diet-induced (FRHFD) hyperglycemias in addition to testicular and splenic morphology in mice. Twenty BALB/c Mice were randomly distributed into four groups (n=5). The groups were fed on a normal diet, FRHFD, FRHFD + 10 g A. vera, and FRHFD + 20 g A. vera for 10 weeks. All the mice were sacrificed a day after the 10 weeks of treatment. The result showed that mice fed on FRHFD plus A. vera had a significantly lower (p<0.05) blood glucose level relative to the FRHFD-fed mice. The mice fed on FRHFD plus A. vera had a significantly lower (p<0.05) blood glucose level relative to the FRHFD-fed mice. Aloe vera was found to ameliorate FRHFD-induced pancreatic islet and acini damage. It also prevented distorted lymphoid cells and testicular damage induced by FRHFD. Aloe vera prevents hyperglycemia and protects pancreatic islets in FRHFD-fed mice. It further prevents immune dysfunction and protects against testicular damage. Hence, A. vera supplementation could be an alternative and/or complementary therapy for hyperglycemia-related disorders.