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All Journal Borneo Journal of Pharmacy
Usman Adam
University of Maiduguri
Medicine & Pharmacology

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Aloe vera Gel Ameliorates Fat-Rich and High Fructose (FRHF) Diet-Induced Pancreatic and Splenic Damage in Mice Nathan Isaac Dibal; Zainab Muhammad Goni; Martha Orendu Oche Attah; Umar Imam; Muhammad Abdullahi; Muzammil Bashir; Usman Adam; Fatima Aisami; Mohammed Shuwa; Sunday Joseph Manye; Madu Nom Gadzama; Musa Samaila Chiroma; Helga Bedan Ishaya
Borneo Journal of Pharmacy Vol. 6 No. 3 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i3.5351

Abstract

High-fat diet alone or in combination with high fructose has been known to induce diabetes, obesity, hypertension, and immune dysfunction. The study evaluates the role of Aloe vera in fat-rich and high fructose diet-induced (FRHFD) hyperglycemias in addition to testicular and splenic morphology in mice. Twenty BALB/c Mice were randomly distributed into four groups (n=5). The groups were fed on a normal diet, FRHFD, FRHFD + 10 g A. vera, and FRHFD + 20 g A. vera for 10 weeks. All the mice were sacrificed a day after the 10 weeks of treatment. The result showed that mice fed on FRHFD plus A. vera had a significantly lower (p<0.05) blood glucose level relative to the FRHFD-fed mice. The mice fed on FRHFD plus A. vera had a significantly lower (p<0.05) blood glucose level relative to the FRHFD-fed mice. Aloe vera was found to ameliorate FRHFD-induced pancreatic islet and acini damage. It also prevented distorted lymphoid cells and testicular damage induced by FRHFD. Aloe vera prevents hyperglycemia and protects pancreatic islets in FRHFD-fed mice. It further prevents immune dysfunction and protects against testicular damage. Hence, A. vera supplementation could be an alternative and/or complementary therapy for hyperglycemia-related disorders.
Co-Authors Fatima Aisami Helga Bedan Ishaya Madu Nom Gadzama Martha Orendu Oche Attah Mohammed Shuwa Muhammad Abdullahi Musa Samaila Chiroma Muzammil Bashir Nathan Isaac Dibal Sunday Joseph Manye Umar Imam Zainab Muhammad Goni