<![CDATA[The CEP approach combines chemical knowledge with entrepreneurial concepts. In the manufacture of macromolecular products, a deep understanding of chemistry is essential. Entrepreneurship education is very important because it raises enthusiasm and motivates students to start a business when they graduate from school. The research objective is to design practical instruction for Chemo-Entrepreneurship (CEP) focusing on the subject of macromolecules. The type of research used for the development of practical instructions in this study is Research and Development. The development method is ADDIE (Analysis, Design, Development, Implementation, and Evaluation). The product developed was validated by six validators in the valid category according to Aiken's V table with a validity value of 0.846. The research subjects in the product trial developed in this study were students of class XII MIPA SMAN 1 Cepu. The assessment of student responses was in the very good category with a percentage of 94.3%. It can be concluded that the CEP-practical guide is feasible to use. The resulting product is expected to be used as a learning resource on the macromolecule topic.]]>
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