Design, Synthesis of New Imidazolium-1,2,3-triazole Hybrid Derivatives as Antimicrobial Agents

Ameer Salem Muttaleb (Faculty of Agriculture, Al-Qasim Green University, Babylon 51001, Iraq)
Nardeen Adnan Berto (Department of Engineering of Polymers and Petrochemicals Industries, University of Babylon, Babylon 51001, Iraq)
Sahar Adeeb Mamoori (Faculty of Agriculture, Al-Qasim Green University, Babylon 51001, Iraq)
Zaman Abdalhussein Ibadi Alaridhee (Department of Medical Laboratory Techniques, College of Health and Medical Techniques, University of Alkafeel, Najaf 54001, Iraq)
Ehab Kareem Obaid (Faculty of Agriculture, Al-Qasim Green University, Babylon 51001, Iraq)
Ali Jabbar Radhi (College of Pharmacy, University of Al-Kafeel, Najaf 54001, Iraq)

Indonesian Journal of Chemistry
Vol 24, No 1 (2024)

New imidazolium salts with 1,2,3-triazole rings (rm1-rm5) were prepared in the current work using a design-driven synthetic procedure scheme. By using analytical techniques such as NMR, IR and spectral information, the chemical structures of target synthesized products were identified using results that were discovered in perfect accord with their assigned structures. The microorganism used in the current study were bacterial strains of Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Bacillus subtilis and Micrococcus luteus, as well as the fungal strains of Aspergillus niger and Candida albicans. All the end products were estimated for their antibacterial activity. The values for the minimum inhibitory concentration (MIC) were confirmed by comparison to the widely used antibiotics fluconazole and ciprofloxacin as control drugs. Particularly, the compounds (rm5) and (rm4) showed observable antibacterial activity. These compounds might offer a brand-new place to start when looking for new antibacterial medications.