<![CDATA[Science learning plays an important role in facilitating the development of 21st century skills. Scholars have paid much attention to the topic in their research activities to gain a comprehensive picture of its role in science education. This study aims to provide an overview of research trends on 21st century skills, especially in science education, through a search for articles that have been published since 2000-2022. The articles consisted of 740 articles derived from the scopus and google scholar databases through searches using the publish or perish search engine. Bibliometric network mapping using visualization of similarities. This bibliometric research is based on stages based on the preferred reporting items for systematic reviews and meta-analyses and network meta-analyses method or abbreviated as preferred reporting items for systematic reviews and meta-analyses. The results showed that 21st century skills research in recent years has increased and occurs at various levels of education and scientific discipline areas and uses a variety of research methods. The findings are expected to provide an overview for other researchers regarding 21st century skills including the number of publications, country of origin, type of publications, research methods, research subjects, types of instruments used, disciplinary fields (science, chemistry, physics, and biology), and learning interventions]]>
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