<![CDATA[Ulva lactuca is rich in bioactive compounds, which are beneficial to humans and other organisms. This study aimed to determine the tyrosinase inhibitory activity of an ethanol extract of U. lactuca seaweed in vitro. This research was carried out in stages, namely, the maceration process of U. lactuca with an ethanol solvent. The extract was liquid-liquid fractionated using n-hexane, chloroform, and water as solvents. The ethanol extracts and fractions were tested for total phenol, total flavonoid, and tyrosinase inhibitory activities. The highest total phenol and flavonoid values were obtained from the n-hexane fraction with values of 9.43±0.27 mgGAE/g and 9.20±0.49 mgQE/g. The highest tyrosinase inhibitory activity was obtained from the n-hexane fraction, with an IC50 value of 127.74±6.47 µg/mL. Active compounds that play an important role in tyrosinase inhibitory activity in the ethanol extract and n-hexane fraction include chalcone, ferulic acid, 4-nitrocinnamic acid, 4-aminobenzoic acid, 2TMS derivatives, 4-hydroxybenzoic acid, 4-tert-butylfenol, 1-tetradecanol, n-hexadecanoic acid methyl ester, palmitic acid, 2-(2-Aminophenyl)-1H-benzimidazole, and 5-methylsalicylic acid. Thus, the n-hexane fraction of U. lactuca could be used as a natural tyrosinase inhibitor.]]>
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