INDONESIAN JOURNAL OF PHARMACY
Vol 16 No 3, 2005

Synthesis of thiazol derivative compounds from α-bromo asil bromida and thiourea

., Tjiptasurasa (Faculty of Mathematics and Natural Sciences, University of Hasanuddin, Makasar Indonesia)



Article Info

Publish Date
01 Jul 2005

Abstract

Thiazol compounds are mostly used as therapeutics in varies effects. These compounds could be synthesized from starting materials that had been produced by local agrochemical industries i.e. alcohol (from the alcohol factories) and urea (from the fertilizer factory). Yielded bromacylbromide could be used to acylate urea derivatives to form aliphatic bromacylurea. When thiourea was used the cyclization product happened i.e. occurred thiazolon derivatives (without bromine). The lost of bromine could be detected by losing of cluster peak of bromine isotope on MS-spectra. The products of these processes were pure, there were 2-aminothiazol- 4-one 2-amino-5-methyl-thiazol-4-one and 2-amino-5-ethyl-thiazol-4-one. Key word : alcohol, thiourea, aminothiazol-4-one.

Copyrights © 2005






Journal Info

Abbrev

3

Publisher

Subject

Medicine & Pharmacology

Description

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas ...