INDONESIAN JOURNAL OF PHARMACY
Vol 14 No 4, 2003

The anticarcinogenic activity of plants compounds

Sugiyanto . (Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta)
B. Sudarto (Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta)
Edy Meiyanto (Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta)
Agung Endro Nugroho (Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta)
Umar A. Jenie (Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta)



Article Info

Publish Date
01 Oct 2005

Abstract

The study was conducted to observe the effect of extracts of ngokilo (Gynura procumbens), beluntas (Pluchea indica), murbei (Morus alba) dan tapak doro (Vinca alba) leaves. Showed anticarcinogenic activity on lung tumor growth of mice. In the nex step, compounds having anticarcinogenic effect was isolated and identified, and evaluated on the cultures of meilomaand Vero cells. The results showed that non-polar fraction of ethanol extract of ngokilo leaves did not have anticarcinogenic activity, whereas the polar fraction show anticarcinogenic activity. At least there were three flavonoids (flavon or flavonol groups) in this polar fraction. It was only two of these flavonoids inhibit the growth of myeloma and Vero cells.Key words : ngokilo, Gynura procumbens, anticarcinogenic, flavonoid.

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Journal Info

Abbrev

3

Publisher

Subject

Medicine & Pharmacology

Description

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas ...