DASYPOGALACTONE, A NEW CHIRALIC C3-SYMMETRIC MACROLACTONE FROM LICHEN USNEA DASYPOGA ROHL.

Ratna Layla Gani (Faculty of Pharmacy, the Pancasila University, Jagakarsa, Jakarta)
Wahyudi Priyono Suwarso (Departement of Chemistry, Faculty of Mathematics and Sciences, the University of Indonesia, Jakarta.)
Karsten Krohn (Fachbereich Chemie und Chemietechnik, der Universitat-GH Paderborn, Warburger Str. 100, D-33098 Padaborn, Germany.)
Markus John (Fachbereich Chemie und Chemietechnik, der Universitat-GH Paderborn, Warburger Str. 100, D-33098 Padaborn, Germany.)

INDONESIAN JOURNAL OF PHARMACY
Vol 12 No 3, 2001

Medicinal plants spread out in Indonesia, however only a part of them have been clinically investigated that exhibited therapeutic effecs. This research was to isolate a new compounds in Usnea dasypoga. A new twentyfour-membered macrolactone composed of three units of unknown fatty acid (2R*,3R*,4S*,7S* or 2S* 3S* 4R*, 7R*)-3,7-dihydroxy-2,4-dimethyloctanoic acid forming a C3-symmetrical lactide was isolated from Indonesian lichen Usnea dasypoga Rohl. The result shown that those compound had been confirmed with the spectroscopic data.Keywords: Natural products isolation, three lactide, lichen