INDONESIAN JOURNAL OF PHARMACY
Vol 17 No 3, 2006

Synthesis of 4-phenyl-3,4-tetrahydro-indeno [2,1]-pyrimidin-2-one (LR-1)

Ritmaleni, Ritmaleni (Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta)
Nurcahyani, Wahyu (Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta)

Article Info

Publish Date
01 Jul 2006

Abstract

The synthetic compound 4-phenyl-3,4-tetrahydro-indeno[2,1]- pyrimidin-2-one 20a (LR-1) was synthesised using Biginelli reaction method. The reaction involved benzaldehyde 6, 2-indanone 2 and urea 7 in acid condition. This condensation reaction yielded 15 % of the product 20, at 133,4-135,0oC of melting point and 0.15 (Et2O : CHCl3 = 1 : 3) of Rf  value.Keywords : benzaldehyde, indenone-2, urea

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Journal Info
INDONESIAN JOURNAL OF PHARMACY
Website

Abbrev

3

Publisher

Universitas Gadjah Mada

Subject

Medicine & Pharmacology

Description

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas ...