SEDATIVE EFFECT OF CLARY SAGE (SALVIA SCLALAREA, L) ON MICE USING AN OLFACTORY AROMATHERAPY

Idajani Hadinoto (Faculty of Pharmacy Unika Widyamandala Surabaya)
Engkun Kuswono (Faculty of Pharmacy Unika Widyamandala Surabaya)
Ani Marlina (Faculty of Pharmacy Unika Widyamandala Surabaya)
Anna Setiawati (Faculty of Pharmacy Unika Widyamandala Surabaya)

INDONESIAN JOURNAL OF PHARMACY
Vol 12 No 1, 2001

A research has been conducted to study the sedative effect of the Clary sage oil (Salvia sclaria, L), using an olfactory aromatherapy method, on male white mice, which have been tested using rotarod, platform and chimney tests. Clary sage oil was given to the male white mice in three different exposed times : 0.5, 1, and 1.5 hours. As a reference standard was used diazepam 170 ug/kg body weight (intraperitoneal). The research indicates that the administration of Clary sage oil can indeed cause the sedative effect. There is also a correlation between the exposure time of Clary sage oil and the sedative effect observed. Key-words : sedative effect, clary sage oil, olfactory aromatherapy