Modeling of p-aminophenol compounds as analgesic antiinflammatory based on biologic activity and structure relationship

., Pudjono (Faculty of Pharmacy, Universitas Gadjah Mada. Yogyakarta, Indonesia)
Susilowati, Sri Sutji (Pharmacy and Medicine, FKIK Universitas Jendral Sudirman. Jl. Dr. Soeparno, Karangwangkal, Purwokerto, 53122)
., Rehana (Pharmacy and Medicine, FKIK Universitas Jendral Sudirman. Jl. Dr. Soeparno, Karangwangkal, Purwokerto, 53122)

INDONESIAN JOURNAL OF PHARMACY
Vol 22 No 2, 2011

This  research  aim  was  to  find  out  the  new  compounds model  of  paminophenol derivates which have analgesic anti-inflammatory activity based on structure  and  biologic  activity  relationship  analysis  by  computation  methods. Seventeen  compounds  of  p-aminophenol  derivates  were  used  in  this  research, and  six  compounds  known  its  analgesic-antiinflammatory  activity  were  used  for determine  QSAR  equation  model.  This  research’s  result  was  a  QSAR  equation that  can  be  using  for  synthesis  the  higher  activity new  compound  of  paminophenol. Key  words  :  p-aminophenol  compounds,  analgesic  anti-inflammatory activity,  structure and activity relationship, QSAR equation, computation methods