Phalerin, a new benzophenoic glucoside isolated from the methanolic extract of Mahkota Dewa [Phaleria macrocarpa (scheff). Boerl.] leaves

Hartati W, Mae Sri ( Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia)
Mubarika, Sofia ( Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia)
Gandjar, Ibnu G ( Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia)
Hamann, Mark T ( Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, USA)
Rao, KV ( Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, USA)
Wahyuono, Subagus ( Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia)

INDONESIAN JOURNAL OF PHARMACY
Vol 16 No 1, 2005

Mahkota Dewa [Phaleria macrocarpa (Scheff). Boerl.] is used traditionally to treat cancers in Indonesia. Extract methanol of the leaves displayed a small LC50 value (63.16 μg/ml) on BST (Brine Shrimp Lethality test) assay; therefore a phytochemical study of this extract was undertaken. A new benzophenoic glucoside was isolated from the methanol extract and identified as 4,5-dihydroxy,4’-methoxybenzophenone-3-0-β-D-glucoside (Phalerin) based on its spectroscopic data. Phalerin was cytotoxic to myeloma cell line (NS-1) (in vitro) having IC50 of 83 μg/ml or 1.9 x 10-1 mM.Key words: Phaleria macrocarpa, Phalerin, myeloma