INDONESIAN JOURNAL OF PHARMACY
Vol 17 No 2, 2006

Antimalaria test of artemisia spp. on Plasmodium falciparum

., Aryanti ( Center of Applied Technology of Isotope and Radiation, BATAN. Jl. Lebak Bulus Raya No. 49 – Jakarta Selatan)
Ermayanti, Tri Muji ( Research Center for Biotechnology-Indonesian Institu of Science)
Priadi, Kartika Ika ( State University of Jakarta)
Dewi, Rita Martaleta ( Research and Eradication Center of Communicable Diseases-Ministry of Health Republic of Indonesia)



Article Info

Publish Date
01 Apr 2006

Abstract

The testing of inhibiton of Plasmodium falciparum by Artemisia annua, A.cina and A.vulgaris isolate and artemisinin content each of plants was conducted. Artemisia leaves extracted from n-hexane and then separated by column chromatography with n-hexane/ethylacetate as eluent. The column result tested to P.falciparum protozoa. The concentrations of agent were 100, 10, 1 and 0,1 μg/mL using sulphadoxin pyrimetamin as a control positive. Then 50 μl of cell suspension added to agent and incubated at 37oC for 30 hours and the number of live skizon calculated from 200 parasite asexual. The result showed that the increasing of agent concentration was increasing of parasite death. Percent of death parasite by agent of 100 μg/mL similar with positive control at the concentration of 300 μg/mL and the death by A.annua was 83.77%, A.cina 78.57 and A.vulgaris was 84.90% meanwhile positive control was 88.09%. The highest of artemisinin content found in A.annua was 4.99.Key words : anti-malaria, Plasmodium falciparum, Artemisia spp.

Copyrights © 2006






Journal Info

Abbrev

3

Publisher

Subject

Medicine & Pharmacology

Description

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas ...