Medical Sains : Jurnal Ilmiah Kefarmasian
Vol 8 No 4 (2023)

FORMULATION AND STABILITY OF STERILE GEL OF AGARWOOD LEAVES EXTRACT (Gyrinops Versteeg (Gilg.) Domke) FOR DIABETIC WOUNDS

Silvi Nurafni (Sekolah Tinggi Teknologi Industri dan Farmasi Bogor)
Antonius Padua Ratu (Sekolah Tinggi Teknologi Industri dan Farmasi Bogor)
Anisya Dwi Shakil (Sekolah Tinggi Teknologi Industri dan Farmasi Bogor)
Siska Fitri Herdiyanti (Sekolah Tinggi Teknologi Industri dan Farmasi Bogor)



Article Info

Publish Date
21 Nov 2023

Abstract

Agarwood leaves contain high levels of secondary metabolites due to increased metabolic processes in agarwood trees infected with fungi. Through this metabolic process, leaves contain secondary metabolites, flavonoids, and tannins. This causes agarwood leaves to have potential as an anti-inflammatory agent for treating diabetic wounds, aimed to formulate a sterile gel preparation of agarwood leaf extract and evaluate its quality, including sterility tests and stability tests (cycling tests) including organoleptic tests, homogeneity, spreadability, adhesive power, viscosity, and pH. A sterile gel formula was prepared with an extract concentration of 4% and variations of Carbopol 940 (gelling agent), namely 0.75%, 1.0%, and 1.25%. The results showed that F1, F2, and F3 were sterile and free of bacterial and fungal growth. The stability test before and after the cycling test in organoleptic tests F1, F2, and F3 were brown, had a distinctive odor of gaharu leaves, and had a soft texture. The homogeneity tests F1, F2, and F3 Homogeneous. The pH values before the cycling test were F1 5.63, F2 4.55, and F3 4.57, whereas after the cycling test, they were F1 5.05, F2 4.87, and F3 4.63. Adhesion time before cycling test F1 02.97 seconds, F2 03.15 seconds, F3 04.86 seconds while after cycling test F1 02.64 seconds, F2 03.04 seconds, F3 03.08 seconds. Spreadability test before cycling test F1 5.4 cm, F2 4.6 cm, F3 3.7 cm, while after cycling test F1 5.0 cm, F2 4.7 cm, F3 3.5 cm ...

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Journal Info

Abbrev

iojs

Publisher

Subject

Medicine & Pharmacology

Description

The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy ...