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All Journal Jurnal Farmamedika (Pharmamedica Journal) Jurnal Farmasi Sains dan Praktis Prosiding University Research Colloquium Medical Sains : Jurnal Ilmiah Kefarmasian
Antonius Padua Ratu
Sekolah Tinggi Teknologi Industri dan Farmasi Bogor
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Environmental Science Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health

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ISOLASI SENYAWA ANTIOKSIDAN EKSTRAK ETANOL BUAH BISBUL ( Diospyros discolor Willd.) Harry Noviardi; Antonius Padua Ratu; Amanda Feby Safitri
Jurnal Farmamedika (Pharmamedika Journal) Vol 3 No 2 (2018): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (547.77 KB) | DOI: 10.47219/ath.v3i2.15

Abstract

Free radicals are the one form of reactive oxygen compounds, which could disrupt the production of DNA, lipid layer on the cell wall, affecting blood vessels, and the production of prostaglandins. Therefore, it takes antioxidants because its ability to inhibit free radicals by means of donating one electron on free radicals. Synthetic antioxidant compounds often have side effects is not good, so much sought after alternative antioxidants from natural ingredients, one of which is bisbul fruit (Diospyros discolor Willd.). Based on research, bisbul fruit has a strong antioxidant activity. The purpose of this study was to isolate the active compound bisbul fruit extracts which had antioxidant activity. The isolation method used thin layer chromatography method and chromatography columns, continued using FTIR spectroscopy method and LC- MS, while the antioxidant activity using the DPPH method. The results obtained had antioxidant activity IC50 53.51 ppm. The spectrum of FTIR spectroscopy was obtained that the compounds had a hydroxyl group which could be assumed as a phenol or alcohol. While the results of the LC-MS spectrum of compounds having a molecular mass of (m+H+) 631.95 m/z. The results showed extract the ethanol bisbul fruit had a strong antioxidant activity and possibility compound antioxidants was Goshonoside F4
Uji Aktivitas Ekstrak Etanol 70% dan Etil Asetat Daun Sukun (Artocarpus altilis (Park.) Fosberg Sebagai Inhibitor Tirosinase. Herson Cahaya Himawan; Antonius Padua Ratu; Maya Miani
Jurnal Farmamedika (Pharmamedika Journal) Vol 1 No 2 (2016): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (713.387 KB) | DOI: 10.47219/ath.v1i2.16

Abstract

Melanin is a substance that gives brown or blackish brown on the skin. Tyrosinase is the main enzyme in biosynthesis of melanin. Utilization of breadfruit leaves based chemical compounds therein such as flavonoids and tannins which are derivates of phenol.Then tested of tyrosinase inhibitory activity.The purpose of this study was to determine the power of inhibition of tyrosinase at ethanol extracts 70% and ethyl acetate extracts of leaves of breadfruit. Acquisition of extraction by maceration, subsequently evaporated by means of separation (rotary vacuum evaporator). Maserate were obtained for a each standard series of concentration 2000; 1000; 500; 250; 125; 62,5; 31,25; 15,63 ppm and kojic acid as positive control with concentration 500; 250; 125; 62,5; 31,25; 15,63 ppm, then each sample tested the inhibitory activity of tyrosinase.Based on the results of the study for the highest tyrosinase inhibitory activity shown by ethyl acetate extract of leaves of breadfruit, because it value smaller IC50 than ethanol extracts 70% of leaves ofbreadfruit. The value IC50 the ethyl acetate extract was 245,43 ppm, while the value IC50 the is 3143,21 ppm. However the activity of tyrosinase inhibition of ethanol extracts 70% and ethyl acetate extract of leaves of breadfruit was lower than kojic acid as positive control that has a value IC50 is 19,36 ppm, because the smaller the value IC50 The greater power inhibition of tyrosinase.
UJI ANTIOKSIDAN EKSTRAK AIR DAN EKSTRAK ETANOL DAGING DAN KULIT BUAH BLEWAH (Cucumis melo L.) Antonius Padua Ratu; Herson Cahaya Himawan; M. Rio Radhi
Jurnal Farmamedika (Pharmamedika Journal) Vol 2 No 1 (2017): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (426.84 KB) | DOI: 10.47219/ath.v2i1.24

Abstract

High content of sitrulin can contribute to oxidative stress as a free radical scavenger. Plants from the Cucurbitaceae family are found in high quantities of Citrulline. One of Cucurbitaceae family is cantaloupe (Cucumis melo L.) The purpose of this study was to determine the antioxidant activity which is optimal in the flesh and rind cantaloupe against extraction methods. The method was used maceration with the ethanol and water, methods of digestion and decocta only with water solvent. The high antioxidant activity was shown by ethanol extract cantaloupe was rind maceration method (583.19 mg/L). In the water extract, rind maceration method of cantaloupe provides antioxidant activity (722.17 mg/L) were significantly different (P<0,05) than the water solvent digestion method and decocta method. However, the antioxidant activity of the flesh and rind extract from cantaloupe is lower than vitamin C.
UJI ANTIOKSIDAN EKSTRAK PIGMEN KAROTENOID DAN SITRULIN PADA KULIT BUAH BLEWAH (Cucumis melo L.) SECARA IN VITRO (METODE DPPH) Antonius Padua Ratu; Nadia Fahmi Silabi; Padmono Citroreksoko
Jurnal Farmamedika (Pharmamedika Journal) Vol 1 No 1 (2016): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (937.027 KB) | DOI: 10.47219/ath.v1i1.39

Abstract

Antioxidants stabilize free radicals with a complete the lack of electrons from free radicals and inhibiting the chain reaction of free radical formation. The purpose this research is to determine the amount of the antioxidant potential of the cantaloupe skin extracts and the effect of different test result of pigment carotene and citrulline in skin cantaloupe extracts to the extraction stage. Cantaloupe skin with drying and without drying treatment is gradually extracted using three solvents (petroleum ether-acetone-water). The highest antioxidant activity shown by extracts water without drying treatment (667.30 mg / L), which was significantly different (P <0.05) with acetone and petroleum ether (996.65 and 2368.26 mg / L). Treatment with drying only on petroleum ether extract (1607.28 mg / L), which provides activity compared with acetone and water (2871.54 and 2290.75 mg / L). However, cantaloupe skin extract antioxidant activity was lower compared with β-carotene and vitamin C. Treatment without drying also give the highest pigments carotenoid shown by extracts aceton (β-caroten 11,32 mg/L, lycopene 0,29 mg/100g) and level of citrulline in water extracts (29,91 mg/L). The difference of effect in simplisia treatment and solvent on the activity of antioxidants and pigments carotenoid levels were significantly different (P <0.05), whereas the levels of citrulline in the simplisia treatment was not significantly different for solvent acetone and significantly different (P <0.05) for solvent petroleum ether and water.
ANALISIS SENYAWA SITRULIN EKSTRAK AIR DAN EKSTRAK ETANOL DAGING DAN KULIT BUAH BLEWAH (Cucumis melo L.) Antonius Padua Ratu; Herson Cahaya Himawan; M. Rio Radhi
Jurnal Farmamedika (Pharmamedika Journal) Vol 1 No 2 (2016): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (171.291 KB) | DOI: 10.47219/ath.v1i2.45

Abstract

Data from the United States Department of Agriculture (USDA) National Nutrient database, that cantaloupe contains amino acids of 0.8 grams / 100 grams. One of the amino acids found in cantaloupe is citrulline which can contribute to oxidative stress as a free radical scavenger. The purpose of this study was to obtain the optimal content of citrulline compound in the flesh and skin of blewah to the method of extraction. The method used is the maceration method with ethanol and water solvent, digestion and dekokta method only with water solvent. Quantitatively, sitrulin is obtained by acid hydrolysis and is reacted with a specific reagent which is 3% diacetyl monoxime in a hot temperature. The reading of the result using the maximum wavelength spectrophotometer is 488 nm. The highest content of citrulline compound was shown by decocta method of aquatic leather water extract (7.72 g / 100g). The citrulline content was significantly different (P <0.05) on the difference in other extraction methods.
AKTIVITAS ANTIHIPERGLIKEMIA REBUSAN DAUN KERSEN (Mutingia calabura L.) DAN DAUN TEH HIJAU (Camellia sinensis) SERTA KOMBINASINYA PADA MENCIT JANTAN Antonius Padua Ratu; Lilik Sulastri; Novriani Debora Siregar
Jurnal Farmamedika (Pharmamedika Journal) Vol 7 No 1 (2022): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v7i1.129

Abstract

Hiperglikemia adalah kondisi tubuh mengalami peningkatan kadar glukosa darah melebihi batas normal. Daun kersen (Mutingia calabura L.) dan daun teh hijau (Camellia sinensis (L.) Kuntze) memiliki aktivitas antihiperglikemia. Metode yang digunakan yaitu maserasi dan rebusan. Ekstrak etanol dan rebusan dilakukan uji fitokimia setelah itu kelompok ekstrak etanol dan rebusan tunggal maupun kombinasinya diujikan ke mencit jantan. Penelitian ini bertujuan untuk mengetahui kelompok yang memberi aktivitas penurunan kadar glukosa dari ekstrak, rebusan tunggal daun kersen dan daun teh hijau maupun kombinasinya dibandingkan dengan kontrol positif. Hasil uji fitokimia dari ekstrak etanol dan rebusan daun kersen serta daun teh hijau menunjukan hasil positif untuk alkaloid, flavonoid, saponin, tanin. Pemberian perlakuan dan induksi sukrosa dilakukan selama 28 hari, pengukuran penurunan kadar glukosa darah mencit pada hari pertama dengan interval waktu 1 jam, 2 jam dan 3 jam dilanjutkan pengukuran tiap 1 minggu sekali 3 jam setelah perlakuan. Penurunan tersebar pada rebusan kersen tunggal (R1) dan penurunan terbesar kombinasi daun kersen dan daun teh (3:1) (R5). Penurunan rata-rata kontrol positif (akarbosa) 60,45%, rebusan daun kersen (R1) 51,62%, kombinasi rebusan 3:1 (R5) 53,44%.
UJI TOKSISITAS DAUN BELUNTAS (Pluchea Indica Less), DAUN KEMANGI (Ocimum Basilicum L.), KULIT BIJI JENGKOL (Archidendron Pauciflorum) DAN KULIT RIMPANG KENCUR (Kaempferia Galanga Linn.) DENGAN METODE BRINE SHRIMP LETHALITY TEST (BSLT) Antonius Padua Ratu; Wirasti Wirasti
Jurnal Farmasi Sains dan Praktis Vol 4 No 2 (2018)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v4i2.2315

Abstract

Metode BSLT merupakan salah satu cara yang cepat dan murah untuk skrining toksisitas dariekstrak tanaman dengan menggunakan hewan laut yaitu larva udang Artemia salina Leach. Metodeini sering dikaitkan dengan metode penapisan senyawa antikanker. Berdasarkan alasan tersebut,maka uji ini sangat tepat digunakan dalam mengawali penelitian bahan alam. Selain BSLT, jugadilakukan penapisan fitokimia. Hasil penelitian dengan metode BSLT dari ekstrak etanol daunbeluntas, kulit biji jengkol, daun kemangi, dan kulit rimpang kencur menunjukkan LC50 masingmasingsebesar 80,33 mg/L, 39,81 mg/L, 46,42 mg/L, dan kurang dari 10 mg/L. Hasil penapisanfitokimia menunjukkan bahwa ekstrak etanol daun beluntas dan kemangi terdapat flavonid, ekstraketanol kulit biji jengkol dan kulit rimpang kencur terdapat alkaloid. Ekstrak etanol kulit rimpangkencur menunjukan aktivitas tertinggi, maka perlu dilakukan isolasi dan identifikasi sehinggadiperoleh senyawa aktif.
Uji Toksisitas Daun Ketepeng (Cassia Alata L.), Kulit Buah Pisang Ambon (Musa Paradisiaca L. Var Sapientum) dan Kulit Rimpang Kencur (Kaempferia Galanga Linn.) dengan Metode Brine Shrimp Lethality Test (BSLT) Antonius Padua Ratu; Eko Mugiyanto
Prosiding University Research Colloquium Proceeding of The 7th University Research Colloquium 2018: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (900.79 KB)

Abstract

Senyawa antikanker dapat dilakukan skrining dengan metode BSLT.Metodei ini merupakan metode awal dan salah satu cara yang cepatserta murah untuk penapisan toksisitas dari ekstrak tanaman denganmenggunakan hewan laut yaitu larva udang Artemia salina Leach.Berdasarkan alasan tersebut, maka uji ini sangat tepat digunakandalam mengawali penelitian bahan alam. Penelitian ini dilakukanuntuk skrining toksisitas daun ketepeng, kulit buah pisang ambon dankulit rimpang kencur dengan metode BSLT sebagai uji awal untukmengetahui bioaktivitas. Selain BSLT, juga dilakukan penapisanfitokimia. Hasil penelitian dengan metode BSLT dari ekstrak etilasetat daun ketepeng, kulit buah pisang ambon, dan kulit rimpangkencur menunjukkan LC50 masing-masing sebesar 59,14 ppm,146,78 ppm, dan kurang dari 10 ppm. Hasil penapisan fitokimiamenunjukkan bahwa ekstrak etil asetat daun ketepeng hanya terdapatflavonoid, ekstrak etil asetat kulit buah pisang ambon terdapatflavonid dan terpenoid; dan kulit rimpang kencur terdapat alkaloiddan terpenoid. Ekstrak etil asetat kulit rimpang kencur menunjukanaktivitas tertinggi dan pontesial sebagai antikanker, maka perludilakukan isolasi dan identifikasi sehingga diperoleh senyawa aktif.Anticancer compounds can be screened by the BSLT method. Thismethod is an early method and one of the quickest and cheapest waysto screen the toxicity of plant extract using marine animals shrimplarvae Artemia salina Leach. Based on these reasons, this researchwas very appropriate to use in initiating the research of naturalmaterials. This research was conducted for toxicity screening ofketepeng leaf, banana peel and kencur rhizome skin by BSLT methodas preliminary test to know bioactivity. Besides BSLT, phytochemicalscreening is also performed. The result of BSLT method from theextract of ethyl acetate of ketepeng leaf, banana peel, and kencurrhizome skin showed LC50 of 59.14 ppm, 146,78 ppm and less than10 ppm, respectively. The results of phytochemical screening showedthat the extract of ethyl acetate of ketepeng leaf contained onlyflavonoid, ethyl acetate extract of banana peel contained flavonoidand terpenoid; and kencur rhizome skin kencur contain alkaloid andterpenoid. The ethyl acetate extract of the skin of kencur rhizome skinshows the highest activity and pontesial as anticancer, it is necessaryto isolate and identify so that the active compound is obtained.
Uji Toksisitas Daun Ketepeng (Cassia Alata L.), Kulit Buah Pisang Ambon (Musa Paradisiaca L. Var Sapientum) dan Kulit Rimpang Kencur (Kaempferia Galanga Linn.) dengan Metode Brine Shrimp Lethality Test (BSLT) Antonius Padua Ratu; Eko Mugiyanto
Prosiding University Research Colloquium Proceeding of The 7th University Research Colloquium 2018: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Senyawa antikanker dapat dilakukan skrining dengan metode BSLT.Metodei ini merupakan metode awal dan salah satu cara yang cepatserta murah untuk penapisan toksisitas dari ekstrak tanaman denganmenggunakan hewan laut yaitu larva udang Artemia salina Leach.Berdasarkan alasan tersebut, maka uji ini sangat tepat digunakandalam mengawali penelitian bahan alam. Penelitian ini dilakukanuntuk skrining toksisitas daun ketepeng, kulit buah pisang ambon dankulit rimpang kencur dengan metode BSLT sebagai uji awal untukmengetahui bioaktivitas. Selain BSLT, juga dilakukan penapisanfitokimia. Hasil penelitian dengan metode BSLT dari ekstrak etilasetat daun ketepeng, kulit buah pisang ambon, dan kulit rimpangkencur menunjukkan LC50 masing-masing sebesar 59,14 ppm,146,78 ppm, dan kurang dari 10 ppm. Hasil penapisan fitokimiamenunjukkan bahwa ekstrak etil asetat daun ketepeng hanya terdapatflavonoid, ekstrak etil asetat kulit buah pisang ambon terdapatflavonid dan terpenoid; dan kulit rimpang kencur terdapat alkaloiddan terpenoid. Ekstrak etil asetat kulit rimpang kencur menunjukanaktivitas tertinggi dan pontesial sebagai antikanker, maka perludilakukan isolasi dan identifikasi sehingga diperoleh senyawa aktif.Anticancer compounds can be screened by the BSLT method. Thismethod is an early method and one of the quickest and cheapest waysto screen the toxicity of plant extract using marine animals shrimplarvae Artemia salina Leach. Based on these reasons, this researchwas very appropriate to use in initiating the research of naturalmaterials. This research was conducted for toxicity screening ofketepeng leaf, banana peel and kencur rhizome skin by BSLT methodas preliminary test to know bioactivity. Besides BSLT, phytochemicalscreening is also performed. The result of BSLT method from theextract of ethyl acetate of ketepeng leaf, banana peel, and kencurrhizome skin showed LC50 of 59.14 ppm, 146,78 ppm and less than10 ppm, respectively. The results of phytochemical screening showedthat the extract of ethyl acetate of ketepeng leaf contained onlyflavonoid, ethyl acetate extract of banana peel contained flavonoidand terpenoid; and kencur rhizome skin kencur contain alkaloid andterpenoid. The ethyl acetate extract of the skin of kencur rhizome skinshows the highest activity and pontesial as anticancer, it is necessaryto isolate and identify so that the active compound is obtained.
FORMULATION AND STABILITY OF STERILE GEL OF AGARWOOD LEAVES EXTRACT (Gyrinops Versteeg (Gilg.) Domke) FOR DIABETIC WOUNDS Silvi Nurafni; Antonius Padua Ratu; Anisya Dwi Shakil; Siska Fitri Herdiyanti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.924

Abstract

Agarwood leaves contain high levels of secondary metabolites due to increased metabolic processes in agarwood trees infected with fungi. Through this metabolic process, leaves contain secondary metabolites, flavonoids, and tannins. This causes agarwood leaves to have potential as an anti-inflammatory agent for treating diabetic wounds, aimed to formulate a sterile gel preparation of agarwood leaf extract and evaluate its quality, including sterility tests and stability tests (cycling tests) including organoleptic tests, homogeneity, spreadability, adhesive power, viscosity, and pH. A sterile gel formula was prepared with an extract concentration of 4% and variations of Carbopol 940 (gelling agent), namely 0.75%, 1.0%, and 1.25%. The results showed that F1, F2, and F3 were sterile and free of bacterial and fungal growth. The stability test before and after the cycling test in organoleptic tests F1, F2, and F3 were brown, had a distinctive odor of gaharu leaves, and had a soft texture. The homogeneity tests F1, F2, and F3 Homogeneous. The pH values before the cycling test were F1 5.63, F2 4.55, and F3 4.57, whereas after the cycling test, they were F1 5.05, F2 4.87, and F3 4.63. Adhesion time before cycling test F1 02.97 seconds, F2 03.15 seconds, F3 04.86 seconds while after cycling test F1 02.64 seconds, F2 03.04 seconds, F3 03.08 seconds. Spreadability test before cycling test F1 5.4 cm, F2 4.6 cm, F3 3.7 cm, while after cycling test F1 5.0 cm, F2 4.7 cm, F3 3.5 cm ...
Co-Authors Amanda Feby Safitri Anisya Dwi Shakil Eko Mugiyanto Harry Noviardi Herson Cahaya Himawan Lilik Sulastri M. Rio Radhi Maya Miani Nadia Fahmi Silabi Novriani Debora Siregar Padmono Citroreksoko Silvi Nurafni Siska Fitri Herdiyanti Wirasti