KOKRISTALISASI KETOPROFEN-ASAM TARTRAT-NaCl UNTUK PENINGKATAN SIFAT KELARUTAN

Muhammad Taqiyyuddin Fahmi (1Kelompok Riset Bahan Aktif Farmasi dan Eksipien Fakultas Farmasi Universitas Jember, Jember, Indonesia)
Eka Deddy Irawan (Kelompok Riset Penghantaran Obat Fakultas Farmasi Universitas Jember, Jember, Indonesia)
Budipratiwi Wisudyaningsih (1Kelompok Riset Bahan Aktif Farmasi dan Eksipien Fakultas Farmasi Universitas Jember, Jember, Indonesia)
Kuni Zu’aimah Barikah (1Kelompok Riset Bahan Aktif Farmasi dan Eksipien Fakultas Farmasi Universitas Jember, Jember, Indonesia)
Yudi Wicaksono (1Kelompok Riset Bahan Aktif Farmasi dan Eksipien Fakultas Farmasi Universitas Jember, Jember, Indonesia)

Jurnal Buana Farma
Vol. 4 No. 2 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi

Ketoprofen is a drug compound with analgesic, anti-inflammatory, and antipyretic effects with very low solubility. The research aims to increase the solubility of ketoprofen using the cocrystallization method. Cocrystallization was carried out using a solvent evaporation method using a tartaric acid coformer and adding the inorganic salt NaCl. Cocrystal solids were characterized using PXRD, DSC, FTIR, and SEM. The cocrystals were evaluated for their solubility and dissolution in distilled water. The characterization results show that the ketoprofen-tartaric acid-NaCl cocrystal solid is a crystalline solid with different solid properties than the solid starting materials of ketoprofen and tartaric acid. Ketoprofen-tartaric acid-NaCl cocrystals showed significantly higher ketoprofen solubility and dissolution (p<0.05) than initial ketoprofen solubility and dissolution