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All Journal Jurnal Buana Farma
Kuni Zu’aimah Barikah
1Kelompok Riset Bahan Aktif Farmasi dan Eksipien Fakultas Farmasi Universitas Jember, Jember, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology

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KOKRISTALISASI KETOPROFEN-ASAM TARTRAT-NaCl UNTUK PENINGKATAN SIFAT KELARUTAN Muhammad Taqiyyuddin Fahmi; Eka Deddy Irawan; Budipratiwi Wisudyaningsih; Kuni Zu’aimah Barikah; Yudi Wicaksono
Jurnal Buana Farma Vol. 4 No. 2 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i2.1021

Abstract

Ketoprofen is a drug compound with analgesic, anti-inflammatory, and antipyretic effects with very low solubility. The research aims to increase the solubility of ketoprofen using the cocrystallization method. Cocrystallization was carried out using a solvent evaporation method using a tartaric acid coformer and adding the inorganic salt NaCl. Cocrystal solids were characterized using PXRD, DSC, FTIR, and SEM. The cocrystals were evaluated for their solubility and dissolution in distilled water. The characterization results show that the ketoprofen-tartaric acid-NaCl cocrystal solid is a crystalline solid with different solid properties than the solid starting materials of ketoprofen and tartaric acid. Ketoprofen-tartaric acid-NaCl cocrystals showed significantly higher ketoprofen solubility and dissolution (p<0.05) than initial ketoprofen solubility and dissolution
Co-Authors Budipratiwi Wisudyaningsih Eka Deddy Irawan Muhammad Taqiyyuddin Fahmi Yudi Wicaksono