<![CDATA[This study presents a comprehensive evaluation of three ensemble models designed to handle imbalanced datasets. Each model incorporates the hybrid nature-inspired imbalance handling algorithm (HNIHA) with matthews correlation coefficient and synthetic minority oversampling technique in conjunction with different base classifiers: support vector machine, random forest, and LightGBM. Our focus is to address the challenges posed by imbalanced datasets, emphasizing the balance between sensitivity and specificity. The HNIHA algorithm-guided support vector machine ensemble demonstrated superior performance, achieving an impressive matthews correlation coefficient of 0.8739, showcasing its robustness in balancing true positives and true negatives. The f1-score, precision, and recall metrics further validated its accuracy, precision, and sensitivity, attaining values of 0.9767, 0.9545, and 1.0, respectively. The ensemble demonstrated its ability to minimize prediction errors by minimizing the mean squared error and root mean squared error to 0.0384 and 0.1961, respectively. The HNIHA-guided random forest ensemble and HNIHA-guided LightGBM ensemble also exhibited strong performances.]]>
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