Estimation of D-dimer, C-reactive protein and ferritin in Covid-19 survivors in a North Indian Hospital, Lucknow, India.

Chetna Singla (Department of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, India)
Dhananjay Tiwari (Department of Biochemistry, Prasad Institute of Medical Sciences, India)
Himali Jha (Department of Medicine, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, India)
Mohammad Mustufa Khan (Department of Basic Medical Sciences, Integral Institute of Allied Health Sciences and Research, Integral University, Lucknow, India)
Sadaf Parveen (Department of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, India)
Roshan Alam (Department of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, India)

Acta Biochimica Indonesiana
Vol. 6 No. 2 (2023): Acta Biochimica Indonesiana

Background: Novel coronavirus disease (COVID-19), the disease caused by SARS-CoV-2, is a highly contagious disease. COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was initially thought to affect only the upper respiratory tract, can affect almost all systems. COVID-19 survivors who are critically ill featured hyper inflammation and the associated biomarkers may be useful for risk stratification. Objective: We aimed to estimate the levels of several biomarkers, including serum C-reactive protein (CRP), D-dimer, and serum ferritin in Covid-19 survivors to reduce the further disease complication and its-associated mortality. Method: This case-control study was conducted on COVID-19 survivors and a control group without a history of Covid-19. The D-dimer and Ferritin were determined by using Mini Vidas Immuno assay analyser and CRP was estimated Dimension RXL Siemens autoanalyzer by Particle Enhanced Turbidimetric Immunoassay. Results: The results indicated that CRP levels were higher in COVID-19 survivors compared to controls (p<0.0001). The mean of D-dimer was found to be elevated in COVID-19 survivors as compared to controls (p<0.0001). Similarly, the ferritin level was also found to be raised in COVID-19 survivors as compared to controls (p<0.0001). Conclusion: Results revealed that COVID-19 survivors had considerably higher mean levels of CRP, D-dimer, and ferritin than controls.