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All Journal Acta Biochimica Indonesiana
Sadaf Parveen
Department of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, India
Biochemistry, Genetics & Molecular Biology

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Evaluation of serum amylase and lipase in diagnosed Covid-19 survivors in a North Indian Hospital, Lucknow, India Nabeela Usmani; Mukhtar Ahmad; Saba Khan; Mohammad Mustufa Khan; Haseeb Ahsan; Sadaf Parveen; Roshan Alam
Acta Biochimica Indonesiana Vol. 6 No. 1 (2023): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.141

Abstract

Background: Coronavirus disease 2019 (Covid-19) is a novel disease caused by coronavirus-2 that causes severe acute respiratory syndrome (SARS-CoV-2). Although it primarily affects the respiratory system, the virus may also target the pancreas. It was suggested that upregulation of angiotensin-converting enzyme II (ACE-II) cell receptors or inflammatory cytokines play a major role in predisposing pancreatic injury in SARS-CoV-2 patients. Our aim was to conduct a critical evaluation of in order to provide an insight into the possibility of pancreatic injury. Methods: A case control study was conducted in the Department of Biochemistry IIMS&R, Integral University, Lucknow. Two groups of subjects (70 adults consisting of 35 Covid-19 survivors and 35 controls) aged between 35 to 70 years were selected for the study with mild to moderate Covid-19 diagnosed using RT-PCR/rapid antigen test and a control group of healthy individuals without history of Covid-19. The serum amylase was determined by the direct substrate method and serum lipase by the turbidimetric UV method using a semi-autoanalyzer. Results: The study showed that the serum amylase (p=0.023) and lipase (p=0.002) levels were significantly elevated in Covid-19 patients compared to the control subjects. The findings indicated that Covid-19 patients had a substantially higher mean serum amylase and lipase levels than the control subjects. Conclusions: The Covid-19 patients are prone to pancreatic injury.
Estimation of D-dimer, C-reactive protein and ferritin in Covid-19 survivors in a North Indian Hospital, Lucknow, India. Chetna Singla; Dhananjay Tiwari; Himali Jha; Mohammad Mustufa Khan; Sadaf Parveen; Roshan Alam
Acta Biochimica Indonesiana Vol. 6 No. 2 (2023): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.172

Abstract

Background: Novel coronavirus disease (COVID-19), the disease caused by SARS-CoV-2, is a highly contagious disease. COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was initially thought to affect only the upper respiratory tract, can affect almost all systems. COVID-19 survivors who are critically ill featured hyper inflammation and the associated biomarkers may be useful for risk stratification. Objective: We aimed to estimate the levels of several biomarkers, including serum C-reactive protein (CRP), D-dimer, and serum ferritin in Covid-19 survivors to reduce the further disease complication and its-associated mortality. Method: This case-control study was conducted on COVID-19 survivors and a control group without a history of Covid-19. The D-dimer and Ferritin were determined by using Mini Vidas Immuno assay analyser and CRP was estimated Dimension RXL Siemens autoanalyzer by Particle Enhanced Turbidimetric Immunoassay. Results: The results indicated that CRP levels were higher in COVID-19 survivors compared to controls (p<0.0001). The mean of D-dimer was found to be elevated in COVID-19 survivors as compared to controls (p<0.0001). Similarly, the ferritin level was also found to be raised in COVID-19 survivors as compared to controls (p<0.0001). Conclusion: Results revealed that COVID-19 survivors had considerably higher mean levels of CRP, D-dimer, and ferritin than controls.
Co-Authors Chetna Singla Dhananjay Tiwari Haseeb Ahsan Himali Jha Mohammad Mustufa Khan Mukhtar Ahmad Nabeela Usmani Roshan Alam Saba Khan