<![CDATA[Dragon fruit, known as Hylocereus undantus (HU), has traditionally been utilized in Banyuwangi, East Java, Indonesia, for addressing gout and rheumatism. Despite its empirical use, there is a lack of reported pharmacological research on this plant. This study aimed to explore the properties of HU extract in treating hyperuricemia, inflammation, and pain. Adenine-potassium oxonate-induced mice were employed to evaluate anti-hyperuricemia activity, measuring uric acid, blood urea nitrogen (BUN), and creatinine serum levels. Carrageenan-induced paw edema in rats was used to assess anti-inflammatory activity, while acetic acid-induced abdominal writhing and hot plate tests were conducted to investigate anti-nociceptive effects. The results revealed that administering HU extracts at 400 mg/kg notably reduced uric acid levels (p<0.01). Moreover, doses of 100, 200, and 400 mg/kg showed significant reductions in BUN and creatinine serum levels (p<0.0001). At a dose of 400 mg/kg, HU extract exhibited a significant anti-inflammatory effect two hours post-administration, manifesting a 15% and 26% reduction in paw edema for male and female mice, respectively (p<0.005, p<0.001). Additionally, doses of 200 and 400 mg/kg demonstrated anti-nociceptive effects in acetic acid-induced abdominal constriction. Furthermore, at 400 mg/kg, the extract exhibited anti-nociceptive activity (p<0.001) three hours post-administration using the hot plate method. This study underscores the potent anti-hyperuricemia, anti-inflammatory, and anti-nociceptive properties of HU. The implications of these findings contribute significantly to comprehending the therapeutic potential of HU.]]>
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