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FORMULASI GEL MENGGUNAKAN SERBUK DAGING IKAN HARUAN (Channa striatus) SEBAGAI PENYEMBUH LUKA Rahmawanty, Dina; Anwar, Effionora; Bahtiar, Anton
Media Farmasi: Jurnal Ilmu Farmasi Vol 11, No 1: Maret 2014
Publisher : Universitas Ahmad Dahlan

Daging ikan haruan (Channa striatus) dipercaya dapat digunakan untuk menyembuhkan luka karena mengandung protein, asam amino esensial, lemak dan asam lemak yang berperan dalam proses penyembuhan luka. Tujuan dari penelitian ini ialah membuat gel yang mengandung serbuk daging ikan haruan sebagai penyembuh luka. Pada penelitian ini digunakan serbuk daging ikan haruan (Channa striatus) sebagai zat aktif sebanyak 1 gram pada formula 1 dan 2 gram pada formula 2. Serbuk daging ikan haruan dibuat suspensi dengan ukuran partikel nanometer dengan metode gelasi ionik menggunakan kitosan dan natrium tripolifosfat, kemudian dibuat menjadi bentuk sedian gel dengan menggunakan gelling agentHPMC. Suspensi yang dihasilkan dilakukan karakterisasi fisika dan kimia. Hasil karakterisasi suspensi formula 1 dan formula 2 adalah sebagai berikut : ukuran partikel berturut-turut 491,8 - 665,5 nm, 481,8 – 828,1 nm; indeks polidispersitas 0,512, 0,456; nilai potensial zeta (+)29,15mV, (+)29,35mV; kedua formula mempunyai partikel berbentuk sferis. Sediaan gel yang dihasilkan dievaluasi aktivitas penyembuhan luka secara in vivo. Dari hasil uji in vivo sediaan gel serbuk daging ikan haruan dapat digunakan sebagai penyembuh luka. Kata Kunci: gel, gelasi ionik, haruan (Channa striatus), kitosan, natrium tripolifosfat, luka.

Pengaruh pemberian fraksi air kulit buah delima (Punica granatum L) terhadap jumlah duktus payudara tikus yang diovariektomi Sunarmi, Sunarmi; Bahtiar, Anton; Wuyung, Puspita Eka
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 8, No 2 (2016)
Publisher : Indonesian Research Gateway

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Pomegranate (Punica granatum L.) is known to have estrogenic activity. Pomegranate peel proven to increase the number of osteoblasts and increases bone density. This study aims to determine the potential of the water fraction of the pomegranate peel as natural Selective Estrogen Receptor Modulators (SERMs) through histological mammary in ovariectomized rats. Ovariectomy method used as a model representing menopause, conducted on 42 rats female Sprague Dawley strain aged 50 days were divided into 7 groups: Sham, OVX, and a group of OVX, each getting estradiol, tamoxifen and fractions water pomegranate peel dose of 50, 100, and 200 mg/kg BW. The results obtained showed water fraction of pomegranate peel did not show any increase in volume and number of mammary ducts.

Pengaruh Pemberian Sari Kacang Hijau (Vigna radiata (L.) R. Wilczek) Terhadap Densitas Tulang dan Jumlah Osteoklas pada Tikus(Rattus norvegicus) yang Diovariektomi Yeyen, Arnita; Bahtiar, Anton; Soetanto, Sriangky
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 8, No 2 (2016)
Publisher : Indonesian Research Gateway

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Greenbean (Vigna radiata (L.) R. Wilczek) contained phytoestrogen suspected has a potential effect as an preventive and alternative treatment of osteoporosis. This study is proposed to determine the effect of extracts of greenbean juice (Vigna radiata (L.) R. Wilczek) on bone density by measuring calcium levels using Atomic Absorption Spectrofotometry (AAS) from femur and the number of osteoclasts collected from histological object which made from ovariectomized rat tibia. Ovariectomy method conducted to represent the osteoporosis condition on 36 female Sprague Dawley rats were divided into 7 groups. Group 1 noticed as Sham was the rat control with surgery without ovariectomy and distilled water, group 2 as negative control is given distilled water and ovariectomized rat control, group 3 as positive control was given estradiol and ovariectomized rat control, group 4 as positive control was given vitamin E and ovariectomized rat control. Group 5, 6, and 7 were given 50 g/100 ml the greenbean juice with volume variation 5 ml/200 gBW, 2.5 ml/200 gBW, and 1.25 ml /200 gBW. Six groups had ovariectomized except sham group and rested for 20 days. Greenbean juice was given orally once daily started from day 21 until day 50. Calcium concentration and osteoclast measurement process taken on day 51. The results of bone calcium levels and osteoclast number showed that greenbean juice did not give significant differences among ovariectomized rats.

Pengaruh pemberian fraksi air kulit buah delima (Punica granatum L) terhadap jumlah duktus payudara tikus yang diovariektomi Sunarmi, Sunarmi; Bahtiar, Anton; Wuyung, Puspita Eka
Jurnal Farmasi Indonesia Vol 8, No 2 (2016)
Publisher : Jurnal Farmasi Indonesia

Pomegranate (Punica granatum L.) is known to have estrogenic activity. Pomegranate peel proven to increase the number of osteoblasts and increases bone density. This study aims to determine the potential of the water fraction of the pomegranate peel as natural Selective Estrogen Receptor Modulators (SERMs) through histological mammary in ovariectomized rats. Ovariectomy method used as a model representing menopause, conducted on 42 rats female Sprague Dawley strain aged 50 days were divided into 7 groups: Sham, OVX, and a group of OVX, each getting estradiol, tamoxifen and fractions water pomegranate peel dose of 50, 100, and 200 mg/kg BW. The results obtained showed water fraction of pomegranate peel did not show any increase in volume and number of mammary ducts.

Pengaruh Pemberian Sari Kacang Hijau (Vigna radiata (L.) R. Wilczek) Terhadap Densitas Tulang dan Jumlah Osteoklas pada Tikus(Rattus norvegicus) yang Diovariektomi Yeyen, Arnita; Bahtiar, Anton; Soetanto, Sriangky
Jurnal Farmasi Indonesia Vol 8, No 2 (2016)
Publisher : Jurnal Farmasi Indonesia

Greenbean (Vigna radiata (L.) R. Wilczek) contained phytoestrogen suspected has a potential effect as an preventive and alternative treatment of osteoporosis. This study is proposed to determine the effect of extracts of greenbean juice (Vigna radiata (L.) R. Wilczek) on bone density by measuring calcium levels using Atomic Absorption Spectrofotometry (AAS) from femur and the number of osteoclasts collected from histological object which made from ovariectomized rat tibia. Ovariectomy method conducted to represent the osteoporosis condition on 36 female Sprague Dawley rats were divided into 7 groups. Group 1 noticed as Sham was the rat control with surgery without ovariectomy and distilled water, group 2 as negative control is given distilled water and ovariectomized rat control, group 3 as positive control was given estradiol and ovariectomized rat control, group 4 as positive control was given vitamin E and ovariectomized rat control. Group 5, 6, and 7 were given 50 g/100 ml the greenbean juice with volume variation 5 ml/200 gBW, 2.5 ml/200 gBW, and 1.25 ml /200 gBW. Six groups had ovariectomized except sham group and rested for 20 days. Greenbean juice was given orally once daily started from day 21 until day 50. Calcium concentration and osteoclast measurement process taken on day 51. The results of bone calcium levels and osteoclast number showed that greenbean juice did not give significant differences among ovariectomized rats.

Pemanfaatan Maltodekstrin Pati Terigu Sebagai Eksipien Dalam Formula Sediaan Tablet dan Niosom Anwar, Effionora; Djajadisastra, Joshita; Yanuar, Arry; Bahtiar, Anton
Majalah Ilmu Kefarmasian Vol. 1, No. 1
Publisher : UI Scholars Hub

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The Use of Maltodextrin from Wheat Starch as an Exipient in Formula Tablet and Niosom dosage form. Wheat starch normally can be used as a tablet filler only, because the flow rate and binding capacity are not good enough. The wheat starch should be treated as follows : protein and amine free Bogasari wheat flour starch were hydrolyzed by α-amylase enzyme (Liquezym EX®) at variable temperature and time incubation to produce maltodextrin with different Dextrose Equivalent (DE) value. The maltodextrin could be used as tablet binder on wet granulation, tablet filler and binder on direct compress, a proniosom carrier to prepare niosom, a tablet filler, binder and disintegrator on direct compress tablet, a sugar coated tablet material. All of the product used active compound as amodel and the quality were evaluated according to the 4thed. of Indonesian Pharmacopeae and other valid references. The result shows that maltodextrin DE 1–5 could be used as a tablet binder which was processed by wet granulation on 2-5% concentration, as a tablet binder and filler which was processed by direct compress on 30-35%; maltodextrin DE 10-15 could be used as a proniosom carrier then continued to niosom preparation with surfactant composition of 2 mmol (1 mmol for span 60 and 1 mmol for cholesterol). The surfactant and drug concentration of 100 mmol/lt and 5 mmol/lt subsequently was proved to loading the drug as much as 81.28%. Maltodextrin DE 15-20 could be used as a tablet filler, binder and disintegrator at 84%, and starch hydrolyzed of DE 35-40 as a sugar coating which was more economical than sugar.

Study of Anti-hyperuricemia, Anti-inflammatory, and Anti-nociceptive Effects of Hylocereus undatus Stem Bark Extract in Animal Models Wahyuni, Tri; Putri, Sartika Harka; Bahtiar, Anton
Pharmaceutical Sciences and Research Vol. 10, No. 3
Publisher : UI Scholars Hub

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Dragon fruit, known as Hylocereus undantus (HU), has traditionally been utilized in Banyuwangi, East Java, Indonesia, for addressing gout and rheumatism. Despite its empirical use, there is a lack of reported pharmacological research on this plant. This study aimed to explore the properties of HU extract in treating hyperuricemia, inflammation, and pain. Adenine-potassium oxonate-induced mice were employed to evaluate anti-hyperuricemia activity, measuring uric acid, blood urea nitrogen (BUN), and creatinine serum levels. Carrageenan-induced paw edema in rats was used to assess anti-inflammatory activity, while acetic acid-induced abdominal writhing and hot plate tests were conducted to investigate anti-nociceptive effects. The results revealed that administering HU extracts at 400 mg/kg notably reduced uric acid levels (p<0.01). Moreover, doses of 100, 200, and 400 mg/kg showed significant reductions in BUN and creatinine serum levels (p<0.0001). At a dose of 400 mg/kg, HU extract exhibited a significant anti-inflammatory effect two hours post-administration, manifesting a 15% and 26% reduction in paw edema for male and female mice, respectively (p<0.005, p<0.001). Additionally, doses of 200 and 400 mg/kg demonstrated anti-nociceptive effects in acetic acid-induced abdominal constriction. Furthermore, at 400 mg/kg, the extract exhibited anti-nociceptive activity (p<0.001) three hours post-administration using the hot plate method. This study underscores the potent anti-hyperuricemia, anti-inflammatory, and anti-nociceptive properties of HU. The implications of these findings contribute significantly to comprehending the therapeutic potential of HU.

Evaluasi Penggunaan Antibiotik dengan Metode Gyssens pada Pasien Stroke Rawat Inap di RSUD Koja secara Retrospektif (Periode KJS dan BPJS) Sitompul, Fransiska; Radji, Maksum; Bahtiar, Anton
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 1, FEBRUARI 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i1.2915

Stroke is a major cause of mortality and morbidity worldwide. Patients with stroke are susceptible to medical complications, especially infections. This study aim to evaluate antibiotic by stroke inpatients hospitalized in RSUD Koja (KJS and BPJS period) with Gyssens methods. The study design is a retrospective cross-sectional. The sample is consisted of 112 medical records from KJS period (July 2013-December 2013) and 74 medical records from BPJS period (January 2014-June 2014) taken by total sampling. The use of antibiotic were analyzed using Chi Square and logistic regression multivariate. The percentage of antibiotic use was 23,11%, mostly were ceftriaxon 33,3%, ceftizozim 7,6% and amoxicillin – clavulanic acid 7,6%. Length of stay more than 7 days was 77,96%. The most common route of antibiotic administration was parenteral (68,67%). Patients that were given antibiotics were,among others,diagnosal by bronchopneumonia (29,33%), pulmonary tuberculosis and 17,6% and urinary tract infection (8,7%). The clinical outcome showed that 69,3% of 186 patients were recovered after antibiotic were given to treat their infections. Gyssen evaluation method showed that rational antibiotic used on KJS period was 77,4% and BPJS periods was 81,3%. There were correlations between rational use at antibiotic and the route of administration, between clinical outcome anduse at diagnosis and route of administration. The conclusion of this study according to Gyssen method is the rational antibiotic influence the clinical outcome (p < 0,05)

Efek Kapsul Ekstrak Etanol Kulit Buah Delima (Punica granatum L.) terhadap Penanda Pembentukan dan Kualitas Tulang pada Wanita Pascamenopause Handayani, Nur Hayati Dwi; Bahtiar, Anton; Louisa, Melva
Jurnal Kefarmasian Indonesia VOLUME 7, NOMOR 2, AGUSTUS 2017
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v7i2.3494

Studies of pomegranate peel (Punica granatum L.), which contain ellagic acid, suggest its ability to increase osteoblast, calcium, and phosphorus in ovariectomized rats. The effects of the pomegranate peel extracts on postmenopausal women was not known. This study was aimed to evaluate the effect of pomegranate peel ethanol extract capsules in the modulation of bone formation and bone quality markers in postmenopausal women. This study is a pilot study of 1st phase of clinical trial using parallel, randomized, double-blind, and placebo controlled design, with 30 subjects. Subjects were randomized to receive commercial capsules of pomegranate peel ethanol extract 2 × 1100 mg/ day or placebo, for 8 weeks. Levels of osteocalcin, calcium, and phosphorus were examined before and after treatment. This study showed that administration of the capsules in postmenopausal women tends to reduce blood osteocalcin level (4,129±5,66 ng/mL on placebo group versus 1,79±5,04 ng/mL on punica group, p=0,245), has not significant on blood calcium level (9,13±0,36 mg/dL placebo group versus 9,21±0,39 mg/dL punica group, p=0,379), has not significant on blood phosphorus level (3,93±0,38 mg/dL placebo group versus 4,12±0,41 mg/dL on punica group, p=0,138), does not affect the function of liver and kidney, and was well tolerated. In conclusion, the commercial capsules is safe, potentially reduce marker of bone formation serum level,and increase bone quality on postmenopausal women.

FORMULASI GEL MENGGUNAKAN SERBUK DAGING IKAN HARUAN (Channa striatus) SEBAGAI PENYEMBUH LUKA Rahmawanty, Dina; Anwar, Effionora; Bahtiar, Anton
Media Farmasi: Jurnal Ilmu Farmasi Vol. 11 No. 1: Maret 2014
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v11i1.1395

Daging ikan haruan (Channa striatus) dipercaya dapat digunakan untuk menyembuhkan luka karena mengandung protein, asam amino esensial, lemak dan asam lemak yang berperan dalam prosesÂ penyembuhan luka. Tujuan dari penelitian ini ialah membuat gel yang mengandung serbuk daging ikan haruan sebagai penyembuh luka. Pada penelitian ini digunakan serbuk daging ikan haruan (Channa striatus) sebagai zat aktif sebanyak 1 gram pada formula 1 dan 2 gram pada formula 2. Serbuk daging ikan haruan dibuat suspensi dengan ukuran partikel nanometer dengan metode gelasi ionik menggunakan kitosan dan natrium tripolifosfat, kemudian dibuat menjadi bentuk sedian gel dengan menggunakan gelling agent HPMC. Suspensi yang dihasilkan dilakukan karakterisasi fisika dan kimia. Hasil karakterisasi suspensi formula 1 dan formula 2 adalah sebagai berikut : ukuran partikel berturut-turut 491,8 - 665,5 nm, 481,8 - 828,1 nm; indeks polidispersitas 0,512, 0,456; nilai potensial zeta (+)29,15mV, (+)29,35mV; kedua formula mempunyai partikel berbentuk sferis. Sediaan gel yang dihasilkan dievaluasi aktivitas penyembuhan luka secara in vivo. Dari hasil uji in vivo sediaan gel serbuk daging ikan haruan dapat digunakan sebagai penyembuh luka. Kata Kunci: gel, gelasi ionik, haruan (Channa striatus), kitosan, natrium tripolifosfat, luka.

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