Hormonal and Laboratory Profile of Polycystic Ovarian Syndrome (Pcos) Women Visiting Fertility Center in Indonesia

Ayu Mulia Sundari (Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Indonesia, Jakarta)
Tri Aprilliana Wulandari (IRSI Research and Training Centre, Jakarta, Indonesia)
Nurul Muhammad Prakoso (Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Indonesia, Jakarta)
Astari Dwiranti (Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Indonesia, Jakarta)
Abinawanto (Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Indonesia, Jakarta)
Arief Boediono (Departemen Anatomi Fisiologi dan Farmakologi, Institut Pertanian Bogor, Jawa Barat)
Hiroaki Funahashi (Faculty of Environmental and Life Science and Technology, Okayama University, Japan)
Anom Bowolaksono (Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Indonesia, Jakarta)

Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan
Vol 18 No 1 (2024): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan

Our study aims to scrutinize the hormonal and laboratory profile of women with PCOS visiting a fertility center in Indonesia. A computerized database of 120 PCOS women and 120 controls was retrospectively reviewed and analyzed. According to analysis, the concentration of AMH and basal LH were significantly more elevated in the PCOS group than in the control group (6.77 vs. 2.05, P<0.001; and 6.8 vs. 5.3, P<0.001, respectively). The level of basal FSH was significantly lower in the PCOS group (5.83 vs. 7.86; P<0.001). After an IVF cycle, PCOS women had significantly higher retrieved oocytes and mature oocytes compared to controls (18 vs. 8, P<0.001; 12 vs. 6, P<0.001). The number of fertilizations, cleavages, and top-quality cleavages were also higher in the PCOS group than in the control group (10 vs. 4, P<0.001; 10 vs. 4, P<0.001; 4 vs. 2, P<0.001). At the blastocyst stage, patients with PCOS had a higher number of blastocysts and top-quality blastocysts than control (9 vs. 4, P<0.001); 4 vs. 1, P<0.01). However, the clinical pregnancy was significantly higher in the control group than in the PCOS group (52.6% vs. 16.7%; P = 0.045).