Jurnal Prima Medika Sains
Vol. 5 No. 2 (2023): December

Anti-inflammatory potential of lemongrass leaves in wound healing

Hasibuan, Patimah Fitriansyari (Unknown)
Tambunan, Andika Zayani (Unknown)
Mutia, Maya Sari (Unknown)



Article Info

Publish Date
11 Dec 2023

Abstract

The inflammatory stage is a normal phase of wound healing; however, inflammation can become chronic and lasts for months or years. This is a post-test with control group design study, divided with 20 male white rats into 4 groups: control group (K), treatment group 1 (P1), treatment group 2 (P2), and treatment group 3 (P3). Lemongrass leaf extract gel, simplicia leaves, stems, and roots of citronella were extracted by maceration using a 1:5 ratio of simplicia to solvent. Gel was applied twice a day (morning and evening) to each group, adhering the formulation. Macroscopic observations were made to assess the wound condition and incision length. The length of the incision wound was measured using a ruler every two days for a span of fourteen days. As the sample size was less than 50, a normality test was performed using the Shapiro-Wilk test, followed by a One-way ANOVA and a Post Hoc test. The study found that wound healing was slowest in the control group but faster in the groups treated with 10% and 15% lemongrass leaf extract. Secondary metabolites at a concentration of 15% had a positive impact on wound healing, whereas at lower concentrations, they only inhibited microorganisms, making them less effective for wound healing.

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Journal Info

Abbrev

JPMS

Publisher

Subject

Health Professions Medicine & Pharmacology Nursing Public Health

Description

Jurnal Prima Medika Sains adalah jurnal ilmiah di bidang kesehatan dan kedokteran yang terbit dua kali dalam setahun yaitu pada bulan Juni dan Desember. Diterbitkan oleh Universitas Prima Indonesia yang secara teknis dikelola Program Studi Magister Kesehatan Masyarakat Fakultas Kedokteran ...