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Anti-inflammatory potential of lemongrass leaves in wound healing Hasibuan, Patimah Fitriansyari; Tambunan, Andika Zayani; Mutia, Maya Sari
Jurnal Prima Medika Sains Vol. 5 No. 2 (2023): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v5i2.4402

The inflammatory stage is a normal phase of wound healing; however, inflammation can become chronic and lasts for months or years. This is a post-test with control group design study, divided with 20 male white rats into 4 groups: control group (K), treatment group 1 (P1), treatment group 2 (P2), and treatment group 3 (P3). Lemongrass leaf extract gel, simplicia leaves, stems, and roots of citronella were extracted by maceration using a 1:5 ratio of simplicia to solvent. Gel was applied twice a day (morning and evening) to each group, adhering the formulation. Macroscopic observations were made to assess the wound condition and incision length. The length of the incision wound was measured using a ruler every two days for a span of fourteen days. As the sample size was less than 50, a normality test was performed using the Shapiro-Wilk test, followed by a One-way ANOVA and a Post Hoc test. The study found that wound healing was slowest in the control group but faster in the groups treated with 10% and 15% lemongrass leaf extract. Secondary metabolites at a concentration of 15% had a positive impact on wound healing, whereas at lower concentrations, they only inhibited microorganisms, making them less effective for wound healing.

The Relationship Between The Use of Cotton Bud and Obturation Cerumen in Prima Indonesia University Faculty of Medicine Students, Class of 2021 Siregar, Gymnastiar; Tambunan, Andika Zayani; Lubis, Yuliani Mardiati; Aishwara, R. Naina
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Volume 10 No.2 November 2024
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/averrous.v10i2.18899

The use of cotton buds is considered to be able to cause cerumen impaction in the external ear canal. However, the use of cotton buds in Indonesia is still quite high. This study aims to examines the relationship between the use of cotton buds and the incidence of cerumen obturans. This study used a cross-sectional study design involving 56 respondents who routinely use cotton buds. Based on the study, a significant relationship was obtained between the frequency and depth (p-value 0.026 and p-value 0.008) of cotton bud use and the incidence of cerumen obturans. Students who frequently use cotton buds have a 5.625 times greater risk of experiencing cerumen obturans compared to those who rarely use them. Students who use cotton buds up to the pars osseus (2/3 of the inner ear canal) have a 4.444 times greater risk of experiencing cerumen obturans compared to those who only use cotton buds up to the pars cartilaginosa (1/3 of the outer ear canal). In conclusion, health education programs regarding the use of cotton buds need to be developed to increase awareness of how to maintain safe and effective ear hygiene.

Pengaruh pemberian ekstrak daun belimbing wuluh (averrhoa bilimbi l.) Terhadap histopatologi dan fungsi ginjal Tikus model hiperurisemia Utomo, Wilbert Waldo; Ginting, Chrismis Novalina; Chiuman, Linda; Tambunan, Andika Zayani; Amir, Widya Pasca
An-Nadaa: Jurnal Kesehatan Masyarakat (e-Journal) Vol 11, No 2 (2024): AN-NADAA JURNAL KESEHATAN MASYARAKAT (DESEMBER)
Publisher : Universitas Islam Kalimantan Muhammad Arsyad Al Banjari Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/ann.v11i2.15505

Penggunaan tanaman obat untuk penyembuhan suatu penyakit didasarkan pada pengalaman yang secara turun -temurun diwariskan dari generasi ke generasi. Hiperurisemia merupakan keadaan dimana terjadinya peningkatan kadar uric acid/ asam urat serum di atas normal, seseorang dikatakan mengalami hiperurisemia bila kadar asam urat dalam darah melebihi kadar asam urat normal, hiperurisemia menjadi permasalahan seluruh lapisan masyarakat baik di Indonesia maupun di seluruh dunia. Beberapa penelitian menyatakan bahwa daun belimbing wuluh memiliki aktivitas antidiabetes, antihiperkolesterolemia, antihipertensi, antimikroba, menurunkan demam, dan nyeri sendi, pada penelitian sebelumnya, ekstrak daun belimbing wuluh diketahui memiliki aktivitas antihiperurisemia. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pemberian ekstrak daun belimbing wuluh (Averrhoa bilimbi L.) terhadap gambaran histopatologi dan fungsi ginjal tikus model hiperurisemia. Jenis penelitin ini merupakan penelitian eksperimen dengan menggunakan pre and post test control group design. Sampel penelitian ini menggunkan hewan uji tikus galur wistar dengan jumlah sampel sebanyak 25 ekor tikus yang dibagi kedalam 5 kelompok dengan kelompok 1 sebagai kontrol negatif tanpa perlakuan, kelompok 2 diberikan alopurinol, kelompok 3 diberikan ekstrak daun belimbing wuluh dengan dosis 100 mg, kelompok 4 diberikan ekstrak daun belimbing wuluh dengan dosis 500 mg dan kelompok 5 diberikan ekstrak daun belimbing wuluh dengan dosis 800 mg. Hasil penlitian menunjukkan pada ekstrak daun belimbing wuluh (Averrhoa bilimbi L.) positif mengandung senyawa alkaloid, steroid, terpenoid, saponin dan flavonoid. Pemberian ekstrak daun belimbing wuluh (Averrhoa Bilimbi L.) efektif terhadap fungsi ginjal tikus model hiperurisemia dimana terdapat penurunan pada kadar kreatin setelah pemberian ekstrak daun belimbing wuluh (Averrhoa Bilimbi L.) p-value < 0,05. Pemberian ekstrak daun belimbing wuluh (Averrhoa bilimbi L.) berpengaruh dalam memperbaiki kerusakan glumerolus ginjal tikus model Hiperurisemia. Dosis ekstrak daun belimbing wuluh (Averrhoa bilimbi L.) yang paling efektif terhadap fungsi ginjal tikus model hiperurisemia adalah dosis 800 mg/KgBB/Hari

The association between cotton bud usage and ear infections among student Aishwara, R. Naina; Tambunan, Andika Zayani; Lubis, Yuliani Mardiati; Siregar, Gymnastiar
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 2 (2024): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i2.5773

This study aimed to determine the relationship between the use of cotton buds and ear complaints in Prima Indonesia University Faculty of Medicine students’ classes in 2021. The method used was analytic observational with a cross-sectional design. Data from this research analysis were obtained from questionnaires filled out by 70 students, consisting of 35 users and 35 non-users of cotton buds. Data analysis was performed using the chi-square test. The results showed a significant association between the use of cotton buds and complaints of itchy ears (p = 0.000, OR = 28.632) and ear pain (p = 0.000, OR = 2.458), but no significant association was found with hearing loss, bleeding, or ear infections. We conclude that the use of cotton buds may increase the risk of itchy and painful ear complaints.

Characteristics of chronic rhinosinusitis patients at the ENT head and neck polyclinic Kristina, Yemima; Lubis, Yuliani Mardiati; Tambunan, Andika Zayani; Rezeki, Naomi Grace
Science Midwifery Vol 13 No 1 (2025): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i1.1794

Background: Chronic rhinosinusitis (CRS) is a long-lasting inflammatory disorder affecting the nasal passages, paranasal sinuses, and upper respiratory tract, marked by symptoms persisting for a minimum of 12 weeks. The purpose of this study is to identify the characteristics of chronic rhinosinusitis patients at the ENT Head and Neck Polyclinic at ROYAL PRIMA Hospital, Medan. Methods: A descriptive research design with a retrospective data collection method was used through secondary data. The population comprised medical records of patients diagnosed with chronic rhinosinusitis at the outpatient polyclinic during the 2021-2022 period, totaling 80 records. Data were collected using purposive sampling, selecting the most complete medical records. Results: The distribution of chronic rhinosinusitis patients showed that the largest age group was 20-29 years (28.4%). Females were more affected (59.7%) than males (40.3%). The most common primary complaint was nasal congestion (28.4%), with the maxillary sinus being the most infected (47.8%). Medical treatment was predominant (55.2%) compared to surgical intervention (turbinectomy) at (44.8%), emphasizing the need for patient evaluation to ensure appropriate treatment. Conclusions: This study provides an overview of chronic rhinosinusitis (CRS) patients, highlighting that those aged 20-29 years are most affected, with a notable prevalence among females (59.7%). The primary complaints include nasal obstruction, facial pain, and headaches, often linked to inflammation and blockage in the sinus pathways. Treatment typically involves pharmacological therapy, while surgery is reserved for those with more severe cases, emphasizing the need for tailored management strategies.

Hubungan Penggunaan Earphone dengan Gangguan Pendengaran Pada Mahasiswa Angkatan 2022 Fakultas Kedokteran Universitas Prima Indonesia Arianti, Ara Safitri; Tambunan, Andika Zayani; Rusip, Gusbakti
Jurnal Impresi Indonesia Vol. 4 No. 9 (2025): Indonesian Impression Journal (JII)
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v4i9.7029

This study aims to examine the relationship between earphone use and hearing impairment among 2022 cohort students of the Faculty of Medicine, Universitas Prima Indonesia. The research employed an analytical observational design with a cross-sectional approach. A total of 37 respondents were selected based on predetermined inclusion and exclusion criteria, including being an active 2022 cohort student, using earphones, and consenting to undergo a pure-tone audiometry test. Data were collected through questionnaires and audiometry examinations, then analyzed using SPSS with normality tests and presented in distribution tables. The results indicate that the majority of respondents were female (78.4%) within the age range of 20–22 years, with most using earphones 1–3 days per week, for 1–3 hours, and at an intensity level below 60%. Audiometric findings revealed that 89.2% of respondents had normal hearing, while 10.8% experienced mild sensorineural hearing loss. These findings suggest that although most respondents remain within the normal category, there is an indication of hearing impairment among students who excessively use earphones. Therefore, this study emphasizes the importance of awareness among students to maintain hearing health by limiting both the duration and volume of earphone usage.

The association between cotton bud usage and ear infections among student Aishwara, R. Naina; Tambunan, Andika Zayani; Lubis, Yuliani Mardiati; Siregar, Gymnastiar
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 2 (2024): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i2.5773

This study aimed to determine the relationship between the use of cotton buds and ear complaints in Prima Indonesia University Faculty of Medicine students’ classes in 2021. The method used was analytic observational with a cross-sectional design. Data from this research analysis were obtained from questionnaires filled out by 70 students, consisting of 35 users and 35 non-users of cotton buds. Data analysis was performed using the chi-square test. The results showed a significant association between the use of cotton buds and complaints of itchy ears (p = 0.000, OR = 28.632) and ear pain (p = 0.000, OR = 2.458), but no significant association was found with hearing loss, bleeding, or ear infections. We conclude that the use of cotton buds may increase the risk of itchy and painful ear complaints.

Hubungan Pengetahuan Kebiasaan Konsumsi Jajanan Cepat Saji Serta Kesehatan Mulut Terhadap Kejadian Tonsilitis pada Anak SMP Swasta Amal Luhur Barasa, Elisabet; Lubis, Yuliani Mardiati; Tambunan, Andika Zayani
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v9i12.55193

Tonsilitis merupakan peradangan umum pada tonsil yang sering terjadi pada anak-anak akibat kebiasaan makan tidak sehat dan kurangnya perhatian terhadap kebersihan mulut. Penelitian ini bertujuan untuk menganalisis hubungan antara pengetahuan mengenai konsumsi jajanan cepat saji dan kebersihan mulut terhadap kejadian tonsilitis pada siswa/i SMP Swasta Amal Luhur Medan. Penelitian menggunakan desain observasional analitik dengan pendekatan cross-sectional, melibatkan 32 sampel siswa/i berusia 12–15 tahun yang diambil secara purposive. Data diperoleh melalui kuesioner yang mencakup pengetahuan kebiasaan makan, kebersihan mulut, dan kejadian tonsilitis, kemudian dianalisis menggunakan uji chi-square. Hasil menunjukkan hubungan signifikan antara pengetahuan kebersihan mulut dan kejadian tonsilitis (p=0,01) serta antara kebiasaan konsumsi jajanan cepat saji dengan tonsilitis (p=0,02). Responden dengan kebersihan mulut buruk memiliki risiko lebih tinggi untuk mengalami tonsilitis dibandingkan dengan yang menjaga kebersihan mulut. Kesimpulannya, pendidikan kesehatan mengenai kebersihan mulut dan dampak jajanan cepat saji diperlukan untuk menurunkan prevalensi tonsilitis di kalangan siswa sekolah. Studi ini merekomendasikan penguatan program edukasi kesehatan serta revisi kebijakan menu kantin sekolah untuk menyediakan pilihan makanan yang lebih sehat.

Antibacterial Activity Test of Gotu Kola Leaf Extract (Centella asiatica) Against Staphylococcus aureus Bacteria Isolated from Wounds of Diabetes Mellitus Patients Fioni; Heldayani, Debby; Lister, Gilbert; Tambunan, Andika Zayani
Jurnal Penelitian Pendidikan IPA Vol 9 No 12 (2023): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i12.6046

Staphylococcus aureus, a gram-positive bacterium, is the causative agent of diabetic foot. Traditional medicine using plants needs much further research, especially for wound healing in diabetes mellitus patients. This study is an experimental laboratory investigation on the efficacy of Gotu kola (Centella asiatica) leaf extract against wound-isolated Staphylococcus aureus. Gotu kola leaf extract (12.5%, 25%, 50%, 75%, and 100%), cefixime suspension (positive control), and sterile distilled water were tested. The results of the research showed the formation of an inhibitory zone from testing Gotu kola leaf extract against Staphylococcus aureus bacteria, where the average inhibitory zone was at concentrations of 12.5% (7.2 mm), 25% (11 mm), 50% (13.7 mm), 75% (14 .3 mm), and 100% (19.5 mm). The higher the concentration used, the larger the inhibition zone formed. Research shows that Gotu kola leaves' active substances inhibit energy formation, nucleic acid formation, cell membrane permeability, structure and function, and membrane protein lysis and damage.

Hubungan Antara Otitis Media Supuratif Kronik Dengan Gangguan Pendengaran Di Poliklinik Tht Rs Royal Prima Medan Zendrato, Ester Junita; Tambunan, Andika Zayani; Rusip, Gusbakti
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i11.62579

Chronic Suppurative Otitis Media (CSOM) is a chronic middle ear infection characterized by tympanic membrane perforation and continuous or recurrent ear discharge. This condition can cause hearing loss if not properly treated. This study aims to determine the relationship between Chronic Suppurative Otitis Media and hearing loss in patients at the ENT Clinic of Royal Prima Hospital Medan. This research is an analytical observational study with a cross-sectional design conducted on 32 patients who met the inclusion criteria. Data were obtained from medical records and pure-tone audiometry results to determine the type and degree of hearing loss. The results showed that most patients experienced conductive hearing loss, with 23 individuals (71.9%), and the most common degree of hearing loss found was mild hearing loss, with 15 individuals (46.9%). The results of the Chi-Square test showed a significant relationship between CSOM and hearing loss (p = 0.012). The recommendation of this study emphasizes the importance of early detection, consulting a doctor for further management, and receiving adequate treatment, as hearing loss can affect communication ability and the quality of life of the sufferers.

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