Genetic Conditions Associated with Intellectual Disability in Indonesian Population: A Review

Ziske Maritska (Department of Biology Medicine, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia)
Atikah M. Ihsan (Department of Pediatric, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia)
Ina Rahmawati (Department of Pediatric, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia)
Perawati Perawati (Department of Pediatric, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia)
Mohammad Hilal Atthariq Ramadhan (Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia)
Bintang Arroyantri Prananjaya (Department of Psychiatry, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia)
Nita Parisa (Department of Pharmacology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia)

SRIWIJAYA JOURNAL OF MEDICINE
Vol. 7 No. 1 (2024): Vol 7, No 1, 2024

Intellectual disability (ID) brings challenges to the affected individuals, their families, and the community at large. It is a multifactorial condition with many contributing factors, namely genetics. This review aims to briefly provide several related genetic conditions for ID in the Indonesian population. Literature studies search relevant articles using PubMed and Google Scholar using the terms ‘intellectual disability’, ‘genetics', ‘Indonesian population’. In Indonesia, the prevalence of children with ID is 1–3%, with 62,011 school-aged children affected with Intellectual Disability. Genetics plays a role in around 25–50% of cases. ID in the Indonesian population is associated with several genetic disorders, namely Duchenne muscular dystrophy (DMD), autism spectrum disorder (ASD), fragile X syndrome (FXS), Down syndrome (DS), Apert syndrome, and subtelomeric chromosomal rearrangements. There is limited research on genetics related to intellectual disability in Indonesia, implying further research is needed.