Journal of Public Health and Pharmacy
Vol. 4 No. 1 (2024)

Antihyperlipidemic and Antiinflammatory Activity of Crude Oil Anguilla Marmorata [Q.] Gaimard in White Rats (Rattus Norvegicus)

Jamaluddin Jamaluddin (Department of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, Indonesia)
Khildah Khaerati (Department of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, Indonesia)
Ihwan Ihwan (Department of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, Indonesia)
Yusriadi Yusriadi (Department of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, Indonesia)
Andi Ratihsekarningrum Siradje (Department of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, Indonesia)
Apriyana Soputra (Department of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, Indonesia)
Novita Christiana Ponganan (Department of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, Indonesia)
Klerensia Defneir Titing (Department of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, Indonesia)
Novianti Batti (Department of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, Indonesia)
Andi Mustika (Department of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, Indonesia)
Andi Alfianto (Department of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, Indonesia)
Moh. Rifki (Department of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, Indonesia)
Janes Krisly (Department of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, Indonesia)
Finta Amalinda (Public Health Study Program, Faculty of Public Health, Muhammadiyah University Palu, Central Sulawesi, Indonesia)



Article Info

Publish Date
18 Mar 2024

Abstract

Fish oil has omega-3 and omega-6 fatty acids, which provide health benefits such as prevention of an increase in total cholesterol, triglycerides, and a decrease in blood HDL, as well as being anti-inflammatory agents in humans. The present study was conducted to determine the antihyperlipidemic and anti-inflammatory activities of eel fish (Anguilla marmorata [Q.] Gaimard) oil extracts on white rats (Rattus norvegicus). To test hyperlipidemia, 25 rats were divided into 5 groups and treated with; 1.5 % PEG 400 (negative control), 20 mg simvastatin (positive control), test doses of 18, 36, and 72 mg/kg. The treatments were carried out for 39 days. In investigating the anti-inflammatory activity, 25 white rats were divided into 5 groups; negative control, positive control, three-dose treatments of 22, 44, and 88 mg/200 g. Blood cholesterol levels were measured and percent inflammation was determined. The results showed that the eel oil extracts led to a decreased of total cholesterol levels 49.60 %, triglycerides 31.15 %, and HDL 14.3 %. The percentage of inflammation values ranged from 31.73 to 54.48 %. The findings indicated that the most effective doses for the antihyperlipidemic effect were 72 mg/ kg, while 22 mg/200 g for the anti-inflammatory activity.

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Journal Info

Abbrev

jphp

Publisher

Subject

Medicine & Pharmacology Public Health

Description

Journal of Public Health and Pharmacy is an national, peer-reviewed journal. It publishes original papers, reviews and short reports on all aspects of the science, philosophy, and practice of public health. It is aimed at all public health practitioners and researchers and those who manage and ...