Background: Optimal levels of public health can be achieved through various efforts, one of which is disease prevention through hand washing with soap (CTPS). School-age children are prone to various diseases due to low CTPS behavior. The aim of the study was to determine the factors related to CTPS among students at SMPN 3 Kota Sabang. Methods: The research method uses descriptive analytics with a cross- sectional approach. This research was conducted at SMPN 3 Kota Sabang with a sample of 85 students in class VII and VIII. Data collection uses  a structured questionnaire instrument. Data analysis uses univariate analysis to display the frequency distribution of each variable and bivariate analysis uses the chi-square test. Result: The results show that there is a relationship between knowledge (p value = 0.001), attitude (p value = 0.002), and the role of health workers (p value = 0.000) with CTPS behavior, and there is no relationship between the teacher's role (p value = 0.462) with CTPS behavior. Recommendation:  It is hoped that School Health Unit (UKS) officers can provide more extensive education  to students about the benefits of CTPS.
                        
                        
                        
                        
                            
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