<![CDATA[Lead significantly affects health because of its sensitivity to the central nervous system and rapid absorption rate. The phytochemicals included in celery, such as flavonoids, may mitigate lead-induced kidney damage. This research aimed to determine how administering celery extract affected the expression of the Caspase-3 gene and the kidney TNF-α gene in Rattus Norvegicus Wistar white rats exposed to lead. The research method true experiment examined the effects of 80 mg/day celery extract on Caspase-3 gene expression and renal TNF-α gene expression in rats exposed to lead. Each of the three groups will include six rats; there will be eighteen male Wistar rats in the study. The study used SPSS 26.0 and the Saphiro Wills test to analyze data on TNF-α and Caspase 3 expression in rats exposed to lead acetate (Pb). The results showed a normal distribution for the negative control group (K-) and the positive control group (K+) and a normal distribution for the treatment group (P). However, the paired t-test showed significant differences in all treatment groups (p <0.05), indicating a normal distribution in the data. The study concludes the impact of celery extract on kidney function in lead-exposed Wistar rats, revealing various active compounds like flavonoids. Despite insignificant caspase 3 reduction, flavonoids showed potential in mitigating lead-induced kidney damage.]]>
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