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All Journal International Journal of Health and Pharmaceutical (IJHP)
Ali Napiah Nasution
Master of Biomedical Science Study Program, Faculty of Medicine, Dentistry, and Health Sciences, Prima Indonesia University, Medan, Indonesia
Nursing Public Health

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Effect of Celery (Apium graveolens L.) Extract Administration on Kidney Function of White Rats (Rattus norvegicus) Wistar Strains Exposed to Lead Shella Selviana Barus; Ali Napiah Nasution; Wienaldi Wienaldi
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 3 (2024): August 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v4i3.339

Abstract

Lead significantly affects health because of its sensitivity to the central nervous system and rapid absorption rate. The phytochemicals included in celery, such as flavonoids, may mitigate lead-induced kidney damage. This research aimed to determine how administering celery extract affected the expression of the Caspase-3 gene and the kidney TNF-α gene in Rattus Norvegicus Wistar white rats exposed to lead. The research method true experiment examined the effects of 80 mg/day celery extract on Caspase-3 gene expression and renal TNF-α gene expression in rats exposed to lead. Each of the three groups will include six rats; there will be eighteen male Wistar rats in the study. The study used SPSS 26.0 and the Saphiro Wills test to analyze data on TNF-α and Caspase 3 expression in rats exposed to lead acetate (Pb). The results showed a normal distribution for the negative control group (K-) and the positive control group (K+) and a normal distribution for the treatment group (P). However, the paired t-test showed significant differences in all treatment groups (p <0.05), indicating a normal distribution in the data. The study concludes the impact of celery extract on kidney function in lead-exposed Wistar rats, revealing various active compounds like flavonoids. Despite insignificant caspase 3 reduction, flavonoids showed potential in mitigating lead-induced kidney damage.
Administration of Eucalyptus to Inhibit the Skin Aging Process of Rats (Rattus Norvegicus) Wistar Strains Exposed to Ultraviolet-B Light Asira Mahrahmi; Tan Suyono; Ali Napiah Nasution
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 3 (2024): August 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v4i2.340

Abstract

Ageing weakens the skin's protective layer, causing pigmentation, inflammation, and cancer. Environmental hazards like pollution and UV radiation harm the skin. Antioxidants, like Eucalyptus globulus, protect against free radicals, making them valuable in medicinal use. The study aimed to investigate the efficacy of Eucalyptus administration in inhibiting skin ageing in rats exposed to ultraviolet-B light. A true experiment was conducted to examine the effectiveness of Eucalyptus in reducing skin ageing in Wistar rats exposed to ultraviolet-B radiation. The study used the "3R Principle" and SPSS to analyse the relationship between collagen quantity, Eucalyptus, and UVB radiation. The study found normal distribution for the control and treatment groups, with a significance of 0.200 and 0.091, respectively. The Levene test showed homogeneity and a T-test result 0.000, indicating a significant difference. The control group had a moderate collagen density, while the treatment group with Eucalyptus extract had a tighter collagen density. The study concludes that the Eucalyptus tree extracts, including tannins, saponins, and flavonoids, have been found to have anti-ageing and collagen-increasing effects in mice exposed to UVB light. The treatment group showed significantly increased collagen density, indicating potential anti-ageing properties in the treatment group.
Co-Authors Asira Mahrahmi Shella Selviana Barus Tan Suyono Wienaldi Wienaldi