Human Immunodeficiency Virus (HIV) is a deadly disease that has spread to various countries including Indonesia, one of which is the province of East Java, especially Ngawi district. The high number of HIV/AIDS transmission cases that occur can be caused by low knowledge in adolescent groups so that they are vulnerable to myths and misinformation about reproductive health, especially about HIV/AIDS continuous increase in cases due to the lack of provision of health information about HIV/AIDS to the public, especially adolescents. The purpose of this study was to determine the effect of HIV/AIDS card match (haicamat) on the knowledge of MTsN 5 Ngawi students. This study is a quasi-experimental research with a non-equivalent control group design. A sampling with simple random sampling was performed on 48 students. Data analysis used is the Mann-Whitney test which received the results of p-value <0.05. There is an effect of HIV/AIDS card match (HAICAMAT) on knowledge about HIV/AIDS in MTsN 5 Ngawi students.
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