Journal of Pharmaceutical and Sciences.
JPS Volume 7 Nomor 3 (2024)

Preliminary Kandungan Glibenclamide dan Metabolitnya 4-trans-hidroksiglibenklamid menggunakan Metode spektrofotometri Uv-Vis

Apriani, Aida (Unknown)
Muna, Tajul (Unknown)
Azhari, Saiful a (Unknown)

Article Info

Publish Date
27 Aug 2024

Abstract

Glibenclamide, another name for glyburide, is one of the antidiabetic drugs oral (ADO) which works by closing the K+-ATP channels in pancreatic beta cells thereby increasing insulin release. 4-trans-hydroxyglibenclamide is the main metabolite of glibenclamide which also has hypoglycemic effects. This study aims to determine the maximum wavelength of glibenclamide and its metabolite 4-trans-hydroxyglibenclamide. The results showed that the maximum wavelength of glibenclamide was at 300.60 nm, while 4-trans-hydroxyglibenclamide was at 299.50 nm and the glibenclamide calibration curve was obtained using the regression equation Y= Y=0.010x+0.001 with a correlation coefficient of 0.998, while 4 -trans-hydroxyglibenclamide Y= 0.0102x-0.0098 with a correlation coefficient of 0.99

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Journal Info
Journal of Pharmaceutical and Sciences.
Website

Abbrev

jps

Publisher

Universitas Tjut Nyak Dhien

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

Description

Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, ...