Cervical cancer patients stage IIIB receive their first chemotherapy treatment. One of the effects of chemotherapy is that it can cause stress. Stress, as a psychological effect, worsens many diseases and pathological conditions and weakens the immune system. This can reduce the cytotoxic activity of T lymphocyte cells and thus increase cell proliferation. The combination of murottal and dhikr therapy can be considered a comprehensive approach to dealing with stress. After listening to murottal, a person may feel more connected to the verses of the Qur'an. Dhikr therapy, as a form of repetition and reflection on the greatness of Allah, can be the next step in strengthening spiritual bonds and relieving stress. Purpose: This study aims to determine the stress level of cervical cancer patients in the first chemotherapy program with murottal and dhikr therapy at Dr. Moewardi Hospital. Method: This type of research is quantitative research with the research design used is Quasy Experiment one group pre test-post test design. The total population of the study was 52 patients. The sample in this study was cervical cancer patients at Dr. Moewardi Hospital, a total of 52 patients using the total sampling technique. This study was conducted in the tulip rooms 4 and 5 of Dr. Moewardi Hospital. Moewardi. on March 25, 2024 – May 13, 2024. Stress assessment indicators using the Perceived Stress Scale (PSS-10). Murottal therapy intervention with a duration of 17 minutes 40 seconds and dhikr with a duration of 2 minutes. Result: Data analysis using parametric testing in the form of a Paired T-Test with a confidence level of 95%. The pretest stress level of murottal and dhikr administration with a mean of 17.17 and a posttest stress level of 13.77. Conclusions: The results of the Paired T-Test were significant at 0.000 <0.05 indicating that there was an effect of murottal and dhikr therapy after the first chemotherapy.
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