<![CDATA[Cigarette smoke has the potential to disrupt hormonal balance, affect spermatogenesis processes, impair spermatozoa viability, and introduce toxic substances to spermatozoa. Avocado fruit contains proteins and vitamins such as vitamin A, B, B1, B2, E, and C, beta-carotene, linoleic acid, lecithin, calcium, iron, pantothenic acid, potassium, phosphorus, niacin, and natural plant oils. The presence of vitamin C and E in avocado is believed to enhance the quantity of Leydig cells and spermatozoa. This study aims to evaluate the potential of avocado juice in optimizing reproductive health in mice exposed to clove cigarette smoke. Male mice (Mus musculus), aged 2 months, weighing ±20g, were randomly divided into 5 groups: K- (negative control), K+ (positive control exposed to cigarette smoke without avocado juice), P1 (mice exposed to cigarette smoke and given avocado juice at a dose of 0.5 ml/20 g BW), P2 (mice exposed to cigarette smoke and given avocado juice at a dose of 0.7 ml/20 g BW), and P3 (mice exposed to cigarette smoke and given avocado juice at a dose of 0.9 ml/20 g BW). Cigarette smoke exposure was administered for 14 days. The results indicate that regular avocado juice consumption can enhance sperm production and reduce spermatozoa abnormalities in mice exposed to clove cigarette smoke. The clinical implications of these findings contribute to a deeper understanding of the potential of avocado juice as a supplement to improve reproductive health, particularly in environments exposed to clove cigarette smoke]]>
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