Jurnal Bioteknologi & Biosains Indonesia (JBBI)
Vol. 10 No. 2 (2023)

POTENTIAL OF HAIR TONIC SARANG BANUA (Clerodendrum fragrans) LEAF EXTRACTS AS ANTI ALOPECIA IN VIVO

Zhafira Dwika Ananda (Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Medan, Medan, Sumatera Utara, Indonesia.)
Rahma Clarisa (Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Medan, Medan, Sumatera Utara, Indonesia.)
Ruth Yohana Saragih (Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Medan, Medan, Sumatera Utara, Indonesia.)
Nadia Givani Br Hotang Hotang (Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Medan, Medan, Sumatera Utara, Indonesia.)
Gusti Ayu Lestari (Department of Biology, Faculty of Mathematics and Natural Science, Universitas Negeri Medan, Medan, Sumatera Utara, Indonesia.)
Yesica Marcelina Romauli Sinaga (Department of Food Science and Technology, Faculty of Food Technology and Agroindustry, Universitas Mataram, Mataram, Nusa Tenggara Barat, Indonesia.)
Murniaty Simorangkir (Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Medan, Medan, Sumatera Utara, Indonesia.)



Article Info

Publish Date
29 Dec 2023

Abstract

Alopecia merupakan suatu keadaan hilang atau tidak tumbuhnya rambut kepala yang dapat terjadi akibat dari penuaan, kekurangan gizi, ketidakseimbangan hormon. Hair tonic merupakan sediaan cair yang digunakan sebagai penumbuh dan penyubur rambut. Sediaan hair tonic sebagai penumbuh rambut membutuhkan antioksidan yang tinggi. Sarang banua (Clerodendrum fragrans) memiliki antioksidan yang tinggi. Riset ini bertujuan untuk mengetahui potensi hair tonic ekstrak daun sarang banua sebagai anti alopecia secara in vivo. Metode riset dilakukan secara in vivo pada tikus putih wistar (Rattus norvegicus). Penelitian ini merupakan penelitian eksperimental Rancangan Acak Lengkap (RAL) dengan 5 kelompok, K– (tanpa ekstrak), K+ (minoxidil 2%), F1 (5% ekstrak), F2 (7,5% ekstrak), dan F3 (10% ekstrak) dilakukan 3 perlakuan. Perlakuan dilakukan setiap hari dioleskan ke tikus yang mengalami stress dan kebotakan alami. Hasil uji ANOVA menunjukkan bahwa F1 (ekstrak 5%) tidak ada perbedaan signifikan dengan K+ (minoxidil 2%). Alopecia is a condition where head hair is missing or not growing which can occur as a result of aging, malnutrition, hormonal imbalance. Hair tonic is a liquid preparation that is used to grow and fertilize hair. Hair tonic preparations as hair growth require high levels of antioxidants. Sarang Banua (Clerodendrum fragrans) contains has high antioxidant. This research aims to determine the potential of hair tonic sarang banua leaf extract as an anti-alopecia in vivo. The research method is in vivo with white wistar rats (Rattus norvegicus). This research was an experimental LSD with 5 groups, K– (no extract), K+ (minoxidil 2%), F1 (5% extract), F2 (7.5% extract), and F3 (10% extract) carried out 3 treatments. The treatment is carried out every day and applied to mice that experience stress and natural baldness. The ANOVA test results showed that F1 (5% extract) had no significant difference from the K+ (2% minoxidil).

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Journal Info

Abbrev

JBBI

Publisher

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions

Description

JBBI is published twice annually and provide scientific publication medium for researchers, engineers, practitioners, academicians, and observers in the field related to biotechnology and bioscience. This journal accepts original research papers, review articles, case studies, and short ...