The concept of the mole is an abstract material that students consider difficult. This study aims to determine the validity and practicality of the flipped classroom learning system based on structured inquiry using LMS Moodle on the mole concept material for phase F of high school. This type of research is educational design research (EDR) with the Plomp model. The flipped classroom learning system based on structured inquiry using LMS Moodle on the mole concept material was validated by 5 validators, namely 3 chemistry lecturers from FMIPA UNP and 2 chemistry teachers from SMAN 2 Padang. The study's results showed a value of 0.93 with a valid category. The practicality of 2 chemistry teachers from SMAN 2 Padang was 97.7% with a very practical category. The practicality of 9 students from SMAN 2 Padang was 90.5% with a very practical category. The results of the study of the flipped classroom learning system based on structured inquiry using LMS Moodle on the mole concept material for phase F of high school have been valid and practical.
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