Background: Tuberculosis is a public health problem both in Indonesia and internationally. Tuberculosis is an infectious disease that can affect anyone and is one of the 10 leading causes of death worldwide. TB ranks second with the highest cases in Indonesia after India. Tuberculosis Infection Control (TBIC) is a form of TB prevention which is the core of safe and high-quality health services. TBIC is often neglected in patient management practice. This study aims to analyze and estimate the effect of tuberculosis infection control training on improving the performance of staff in health facilities. Subjects and Method: The meta-analysis was carried out using the PICO format including: (1) Population: Health personil; (2) Intervention: TBIC Training; (3) Comparison: No TBIC training; and (4) Outcome: Performance. Article searches were carried out using several databases such as Google Scholar, PubMed, and Elsevier. Search for articles from 20 October 2022 to 21 January 2023. Keywords used: “Tuberculosis infection control training” OR “Performance” AND “Health personel” AND “Health facility” AND “Multivariate” AND “Cross-sectional”. The inclusion criteria for the included articles were full text articles, relationship measures using multivariate analysis (aOR), English articles with a cross-sectional design, and article publications in 2012-2022. Articles are collected using PRISMA flow diagram guidelines. Data were analyzed using the Review Manager 5.3 application. Results: A total of 13 cross-sectional studies, from the continents of Asia and Africa. Nine articles from East Africa (Ethiopia), 2 articles from West Africa (Nigeria), 1 article from Central Africa (Cameroon), and 1 article from South Asia (Nepal). The results showed that health personil who received TBIC training had a 2.35 times better chance of performance compared to health personil without training, and this result was statistically significant (aOR= 2.35; 95% CI= 1.96 to 2.81; p <0.001). Conclusion: Tuberculosis infection control training can improve the performance of workers in health facilities. Key words: Health personil, tuberculosis infection control training, and health facilities
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