ANTIHYPERGLICEMIA ACTIVITY OF WATER FRACTION, ETHYL ACETATE FRACTION, AND N- HEXANE FRACTION OF SPINACH LEAVES EXTRACT (Amaranthus Cruentus L) ON MALE MICE SWISS

Tita Nofianti (School of Pharmacy, STIKes Bakti Tunas Husada Tasikmalaya, Cilolohan street no 36 Tasikmalaya, Indonesia)

Jurnal Farmasi Galenika
Vol 2 No 02 (2015): JURNAL FARMASI GALENIKA

The activity test ofthe water fraction, ethyl acetate and n-hexane fraction of spinach leaves (Amaranthus cruentus L) has been conducted using the glucose tolerance method on male mice Swiss webster strain. The dose were water fraction 0.086 g/kg bw, ethyl acetate fraction 0.03g/kg body weight and n-hexane fraction 0.055 g/kg bw. Time measurement of blood glucose levels was conducted every 30 minutes for 120 minutes using a glucometer. The results showed that administration of water fraction, ethyl acetate fraction and n-hexane fraction of spinach leaves can lowering the blood glucose level of white male mice. While the best group that lowering the blood glucose level was ethyl acetate fraction 0,03 g/kg bw when compared to water fraction and n-hexane fraction. It can be concluded that spinach leaves showed antihyperglicemia.