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INDONESIA
Jurnal Farmasi Galenika
Published by Universitas Bhakti Kencana
ISSN : 24069299     EISSN : 25794469     DOI : https://doi.org/10.70410/jfg
Core Subject : Health,
Medicine & Pharmacology Public Health
The aim of JFG is to become a media for the publication of articles on Pharmaceutical and related practice-oriented subjects in the pharmaceutical sciences and technology. The scope of the journal is Pharmaceutical sciences, its research and its application. The journal aims to cover the latest outstanding developments in the field of Pharmaceutical science and Technology but not limited to the following branches: Pharmaceutics Pharmaceutical technogy International Regulatory Validation Techniques Industrial Pharmacy Nanotechnology Novel Drug Delivery Systems Quality Control Quality Assurance BioTechnology Bioinformatics Proteomics Biochemistry Pharmacognosy Herbal technology Pharmacology Toxicology Pharmacy Practice Pharmacoinformatics Phytochemistry Pharmaceutical Analysis Chiral Chemistry Synthetic Chemistry Drug Development Clinical Pharmacy Pharmacogenomics Pharmacetical Engineering
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 190 Documents
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KARAKTERISASI MINYAK BIJI LABU KUNING (Cucurbita pepo L.) HASIL EKSTRAKSI DENGAN ALAT SOXHLET Muhammad Nur Abdillah
JURNAL FARMASI GALENIKA Vol 1 No 01 (2014): JURNAL FARMASI GALENIKA
Publisher : Universitas Bhakti Kencana

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Vegetable oil that produced from pumpkin seed can be used to be a raw material of industrial manufacture such as foods, cosmetics and pharmaceutical industries. The aim of this research is to characterize the physical and chemical properties of pumpkin seed oil extracted using Soxhlet apparatus. This research hopefully can give the information about the quality of pumpkin seed oil from Soxhlet apparatus extraction so that the data can be used on the next research. Characteristics of pumpkin seed oil (Cucurbita pepo L.) from Soxhlet apparatus extraction had been researched by identified the parameter of physical properties such as color by chromameter, boiled and smoke points, specific gravity by picnometer, refractive index by refractometer, water content, and impurities; chemical properties such as acid value, peroxide value, iodine value, saponification value; functional groups by Fourier Transform Infrared (FTIR). Rendemen of the extraction was 35,35(±2,8)% at 60oC for 4-6 hours. The physical properties were: color: the value of L: 52,79(±5,09), a: +2,86(±2,22), b: +26,04(±0,70); smoke point: 119,50(±0,70)oC, boiling point: 209,00(±4,24)oC; specific gravity 0,92(±8,23x10-4); refractive index 1,46(±8,21x10-4) at 25,85(±0,05)oC; water content 8,85(±0,76)%; impurities 11,74(±0,34)%; and the chemical properties were: acid value 2,76(±0,24) mg KOH/g; peroxide value: 49,56(±8,99)meq/1000g and 24,78(±4,50)mmol/1000g; iodium value 13,38(±1,47)mg I2/100g; saponification value 357,94(±62,97)mg KOH/g; has the specific stretching ethylenic groups at 3007cm-1 andasymetric stretching of ester carbonyl groups -C=O at 1745-1659cm-1, also asymetric stretching of ester C-O-C at 1235-1105cm-1 and bending of ester O-C-O at 592cm-1 on fingerprint region.
KARAKTERISASI PATI BIJI BUAH DURIAN, BIJI BUAH NANGKA, DAN BIJI BUAH ALPUKAT R Herni Kusriani
JURNAL FARMASI GALENIKA Vol 1 No 01 (2014): JURNAL FARMASI GALENIKA
Publisher : Universitas Bhakti Kencana

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Starch as one of the excipients in the pharmaceutical plays an important role. One of the source of starch that is widely used is from cassava. This study aims to look for other sources of starch from local materials which can ensure the quality and availability, such as the seeds of durian, jackfruit, and avocado. The methods of this research include the characterization of starch and proximate analysis (moisture, ash content, fat content, protein content, and fiber content). The results showed that the starch from grains rendemen durian, jackfruit, and avocados were respectively 10, 16, and 4%. Proximate analysis showed that the protein content of the starch grains durian, jackfruit,and avocado respectively were 14.58; 13.56; and 17.13%, while the fat content of starch grains durian, jackfruit, and avocado respectively were 3.55; 3.68; and 4.95% and fiber content of starch grains durian, jackfruit, and avocado were 8.80; 8.55; and 9.10%. It was concluded that macronutrient containsof avocado seed greater than durian and jackfruit seeds, although rendemen of avocado seed starch was lower than durian and jackfruit seed.
PENETAPAN KADAR KURKUMINOID DALAM SEDIAAN SIRUP TEMULAWAK (Curcuma xanthorizzha Roxb) DENGAN SPEKTROFOTOMETRI R Herni Kusriani
JURNAL FARMASI GALENIKA Vol 1 No 01 (2014): JURNAL FARMASI GALENIKA
Publisher : Universitas Bhakti Kencana

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Curcuminoid is the compound contained in temulawak(Curcumaxanthorizzha Roxb). Some research reports indicate that curcumin has various pharmacological activities such as hepatoprotector, anti-inflammatory, antibacterial, antioxidant, and etc. Study on thedetermination of curcuminoid using visible spectrophotometer was done to find outthe content of curcuminoid in 5sample temulawak syrup(Curcumaxanthorizzha Roxb) on the market. Measurements performed at wavelength of 425nm.The results showed that the limits of detection and quantitation of analytical methods were 0.27 and 0.91ppmand the percentage of recoverywas94.05% ±0.97%. The content of curcuminoid in 5 samples were350 ppm,347 ppm; 308 ppm; 163 ppm; dan 359 ppm.
FORMULASI SEDIAAN KRIM EKSTRAK ETANOL DAUN TEH HIJAU (Camellia Sinensis L.) SEBAGAI PELINDUNG SINAR ULTRA VIOLET Dadih Supriadi
JURNAL FARMASI GALENIKA Vol 1 No 01 (2014): JURNAL FARMASI GALENIKA
Publisher : Universitas Bhakti Kencana

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Green tea (Camellia Sinensis L.) is known to have several pharmacological activities of which are antioxidants. This research aims to make preparations cream formula ethanol extract of green tea leaves as a protection against ultraviolet light exposure. Cream made using the material forming wax cream fan sew-p 10%. Organoleptic testing cream preparation includes observation of discoloration, odor, pH, and homogeneity during storage. The organoleptic evaluation of preparation has been done includes observation of changes in color, odor, pH, and homogeneity during storage. Based on the results showed that ultraviolet light protective cream with dosage of extract concentration of 2%, 4%, 6%, and 8% stable during storage. Viscosity evaluation showed an increase in viscosity during 28 days of observation. The results of effectiveness evaluation with ultraviolet spectrophotometric method showed that increasing concentration of green tea leaf extract in the preparation can increase the value of SPF (Sun Protector Factor). The value of SPF were 2.32 for 2% extract; 5.09 for 4% extract; 6.71 for 6% extract; 7.48 for 8% extract. From these results, it can be concluded that the formula contained 2%, 4%, 6% and 8% extract as a protective of ultraviolet light.
AKTIVITAS ANALGETIKA EKSTRAK N-HEKSANA, ETIL ASETAT DAN ETANOL BUAH BELIMBING WULUH (Averrhoa bilimbi L.) PADA MENCIT JANTAN GALUR SWISS WEBSTER DENGAN METODE GELIAT Patonah Hasbalah
JURNAL FARMASI GALENIKA Vol 1 No 01 (2014): JURNAL FARMASI GALENIKA
Publisher : Universitas Bhakti Kencana

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Abstract

Tests were conducted to Averrhoa bilimbi L. as analgesic activity in male Swiss Webster mice by Siegmund method. A number of 55 male mice were randomly divided into 11 groups: group 1 (received suspension drug carrier), group 2 (received aspirin dose of 65 mg / kg bw), group 3-5 (received n-hexane extracts doses of 5, 50 , 500 mg / kg bw respectively orally), group 6-8 (received ethyl acetate extracts doses of 5, 50 , 500 mg / kg bw respectively orally), and group 9-11 (received ethanol extracts doses of 5, 50 , 500 mg / kg bw respectively orally). Induction of pain using 1% acetic acid dose of 262.5 mg / kg bw intraperitoneally. Data amount of stretching for 1 hour each group were analyzed statistically. The results showed that the Averrhoa bilimbi L. extracts of n-hexane, ethyl acetate and ethanol showed analgesic activity. Ethanol extract of Averrhoa bilimbi L. dose of 500 mg / kg bw showed analgesic activity comparable to aspirin.Based on the results of this study concluded that Averrhoa bilimbi L. have analgesic activity. Averrhoa bilimbi L. extract as the best analgesic is ethanol extract dose of 500 mg / kg bw.
POTENSI EKSTRAK BUAH BELIMBING WULUH (Averrhoa Blimbi L.) SEBAGAI ANTIHIPERGLIKEMIA PADA HEWAN MENCIT SWISS WEBSTER Ika Kurnia
JURNAL FARMASI GALENIKA Vol 1 No 01 (2014): JURNAL FARMASI GALENIKA
Publisher : Universitas Bhakti Kencana

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Abstract

Antihyperglicemia activity tests were conducted for Averrhoa bilimbi L. fruit extract in male Swiss Webster mice using glucose tolerance tests. This study aimed to determined the effect of Averrhoa bilimbi L. fruit extracts using 3 different types polarity of solvent, namely n-hexane, ethyl acetate and ethanol on blood glucose levels of mice were loaded with 50% glucose solution. Test animals were randomly divided into 12 groups: group 1 (normal group received the drug carrier), group 2 (the positive group received drug carrier), group 3 (glibenclamide 0.65 mg / kg bw), group 4-12 were test group received the extract n-hexane, ethyl and ethanol of Averrhoa bilimbi L. fruit extracts each dose of 5, 500, and 750 mg / kg bw respectively. Blood glucose levels were measured every 30 minutes for 120 minutes. The results showed that the ethanol extract of Averrhoa bilimbi L. fruit extracts doses of 5, 500 and 750 mg / kg bw showed the best antihiperglikemia activity.Based on the resultsof this study concludedthatAverrhoa bilimbi has antihyperglycemic activity.
PEMANTAUAN REAKSI OBAT MERUGIKAN DARI PENGGUNAAN OBAT ANTIINFLAMASI TERHADAP GASTROINTESTINAL Yani Mulyani
JURNAL FARMASI GALENIKA Vol 1 No 01 (2014): JURNAL FARMASI GALENIKA
Publisher : Universitas Bhakti Kencana

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Anti-inflammatory drugs are often prescribed in hospitals, especially in adult patients to treat pain, especially in joint disease. Anti-inflammatory drug that is used long term can cause gastrointestinal disturbances. This study aims to monitor adverse drug reactions from the use of anti-inflammatory drugs on the gastrointestinal. This study is a descriptive study using concurrent data is taken from the order signals in the inpatient unit involving 52 patients. This study includes several stages of the preliminary survey, the determination of medicine criteria, criteria of drug use, setting criteria of patients, collecting data from the order signal, there is a data source, data analysis and conclusions. The results showed that of the 52 patients there are 17.31% of patients get anti-inflammatory drug therapy (consisting of 11.53% receiving nonsteroidal anti-inflammatory drugs and 5.77% received antiinflammatory steroid) and received a gastrointestinal drug without gastrointestinal indications. Gastrointestinal drugs used were antiemetic 23.61%, 19.44% antacids, antiflatulen, 16.67, kolagogum 8.33%, 12.50% other gastrointestinal drugs, antidiarrheal 11.11%, 2.78% laxative, and digestan koreletikum 2.78%. Based on the results of this study concluded that the use of anti-inflammatory drugs either steroids or nonsteroidal can lead to gastrointestinal adverse drug reaction it gained 17.31%
AKTIVITAS ANTIBAKTERI MADU HITAM PAHIT DAN MADU HITAM MANIS TERHADAP Escherichia coli dan Staphylococcus aureus Sri Peni Fitrianingsih
JURNAL FARMASI GALENIKA Vol 1 No 02 (2014): JURNAL FARMASI GALENIKA
Publisher : Universitas Bhakti Kencana

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Antibacterial activity of bitter-black honey and sweet-black honey against Escherichia coli and Staphylococcus aureus was investigated. The purpose of this study was to measure the antibacterial activity, Minimum Inhibition Concentration (MIC), and the action of bitter-black honey and sweet-black honey that collected from Borneo. Disc diffusion methode was used to measure the antibacterial activity and MIC of honeys. Turbidimetric assaywas used to measure the antibacterial action of honeys. Results showed that bitter-black honey and sweet-black honey possess antibacterial activity against E.coli and S.aureus. MIC value of bitter-black honey was 3,4%-3,8%. And MIC value of sweet-black honey was 4,4%-4,8%. Antibacterial action of two types of honey at concentration 6,25% against S.aureus was bacteriostatic. Bitter-black honey had higher antibacterial activity than sweet-black honey.
SKRINING POTENSI ANTIBAKTERI EKSTRAK ETANOL BUAH NANGKA MUDA (ARTOCARPUS HETEROPHYLLUS LAMK.) TERHADAP BAKTERI PENYEBAB DIARE Umi Yuniarni
JURNAL FARMASI GALENIKA Vol 1 No 02 (2014): JURNAL FARMASI GALENIKA
Publisher : Universitas Bhakti Kencana

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Empirically young jackfruit can treat acute diarrhea . This study aims to investigate the antibacterial activity of ethanol extracts young jackfruit against Escherichia coli and Shigella dysenteriae which causes diarrhea .Antibacterial activity test performed by the agar diffusion method at concentrations of 50, 75, 100 and 125 mg/mL and tetracycline was used as a standard. Thin layer chromatography was conducted to determine the marker compounds of young jackfruit.Minimum Iinhibitory Concentration (MIC) value of ethanol extract of young jackfruit against E. coli of 1.25 mg/mL and 2.5 mg/mL against S. dysenteriae .Young jackfruit ethanol extract at a concentration of 50 mg/ml comparable to tetracycline 36.30 mg/mL for E. coli and 35.48 mg/mL against S. dysenteriae.Ethanol extract of young jackfruit positive contribution to group phenolic compounds which pink flouresensed under 366nm UV and gave black color spot with FeCl3 at value of Rf 0.77.Ethanol extract of young jackfruit gave antibacterial activity against Escherichia coli and Shigella dysentriae and showed the content of phenolic compounds with Rf value of 0,77.
AKTIVITAS ANTIOKSIDAN DAN KANDUNGAN SENYAWA FENOLAT BIJI JAMBLANG (Syzygium cumini (L.) Skeels) Lia Marliani
JURNAL FARMASI GALENIKA Vol 1 No 02 (2014): JURNAL FARMASI GALENIKA
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Jamblang (Syzygium cumini (L.) Skeels) is one of local plantsfrom Indonesia that is rare cultivated. Some compounds contained in Jamblang is probably potential to have antioxidant activity. This study was conducted to determine the antioxidant activity and content of phenolic compounds of jamblang seeds. Extraction was done by reflux method using water solvent and dried by freeze drying method. Antioxidant activity was tested qualitatively and quantitatively by reduction of free radical 1-1-diphenyl-2 picrylhydrazyl (DPPH) method. Antioxidant activity was qualitatively testedby Thin Layer Chromatography using butanol-acetic acid-water (4: 1: 5) as mobile phase and 0.2% DPPH in metanol as spotting agent. Antioxidant activity was quantitatively measured by UV-visible spectrophotometry at λ 516 nm and determined by the IC50 value. Vitamin C was used as comparison. The content of phenolic compounds analysis was done qualitatively and quantitatively. The Qualitative test was done by thin layer chromatography using butanol-acetic acid-water (4: 1: 5) as mobile phase and 10% FeCl3as spotting agent. Determination of total phenolic compound was using the Folin-Ciocalteu reagent and measured by UVvisible spectrophotometry at λ 765 nm. The IC50 values of jamblang seed extract and vitamin C respectively were67.098 ppm and 6.98 ppm. Phenolic compound was suspected as active antioxidants compound. Total phenolic content of seed extractis 119.251 ± 2.494 mg / g.

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