Jurnal Farmasi Galenika
Vol 2 No 02 (2015): JURNAL FARMASI GALENIKA

MICROMERITIC CHARACTERISTIC OF SPHERICAL AGGLOMERATED ACETAMINOPHEN CRYSTAL BY SPHERICAL NEUTRALIZATION METHOD

Lilis Tuslinah (Department Of Pharmacy, STIKesBakti Tunas HusadaTasikmalaya, Indonesia)

Article Info

Publish Date
21 Mar 2017

Abstract

Direct tableting method needs to increase compressibility and flowability of the bulk powder in order to maintain a steady supply of powder mixture to tableting machine and sufficient mechanical strength of compacted tablet. Acetaminophen exhibits poor water solubility and flow properties.Spherical agglomerates of acetaminophen were prepared by neutralization method. Spherical agglomerates were characterized by differential scanning calorimetry, Infrared spectroscopy and X-ray diffactometry. Micromeritic behavior of pure and spherical agglomerates of acetaminophen were carried out. Spherical agglomerates exhibited improved micromeritic properties compared with pure Acetaminophen.

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Journal Info
Jurnal Farmasi Galenika
Website

Abbrev

jfg

Publisher

Universitas Bhakti Kencana

Subject

Medicine & Pharmacology Public Health

Description

The aim of JFG is to become a media for the publication of articles on Pharmaceutical and related practice-oriented subjects in the pharmaceutical sciences and technology. The scope of the journal is Pharmaceutical sciences, its research and its application. The journal aims to cover the latest ...