The VUCA (Volatility, Uncertainty, Complexity, Ambiguity) era has changed the way businesses operate, including in the realm of E-Commerce. These changes raise new challenges, such as intense competition, market uncertainty, and the need for rapid adaptation. In this context, Islamic business ethics offers relevant and adaptive guidance through values such as honesty (ṣidq), justice (ʿadl), responsibility (amānah), and transparency (shafāfiyyah). This research aims to analyze the application of the Islamic business ethics perspective in E-Commerce operations in the VUCA era. This article uses a qualitative approach, with a library research method to integrate Islamic ethical principles. The research results show that the application of Islamic business ethics can strengthen consumer trust, increase operational stability, and create a sustainable business model amidst uncertainty. This article concludes that the integration of Islamic business ethical values is not only relevant but also provides innovative solutions to answer the challenges of the VUCA era.
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