<![CDATA[Excessive amounts of free radicals will cause pathological effects that result in degenerative diseases. The free radical oxidation process can be neutralized by antioxidants. Antioxidants are compounds that have the ability to eliminate, clean and resist the effects of free radicals. Matoa leaf plants are used as traditional medicine to treat various diseases. The leaves of matoa contain active compounds in the form of saponins, flavonoids and tannins. Flavonoids can act as antioxidants because they can provide an electron to free radicals. The aim of this research was to determine the total flavonoid content and antioxidant activity of matoa (Pometia Pinnata) leaf ethyl acetate extract which was tested using the DPPH free radical reduction method. The extraction process was carried out using the maceration method using ethyl acetate solvent in a ratio of 1:5. Determination of total flavonoid levels was carried out by adding AlCl3 and sodium acetate reagents. The antioxidant activity test was carried out using the DPPH free radical reduction method with quercetin as a comparison. Analysis was carried out using a UV-Vis spectrophotometer. Research shows that the yield of matoa leaf ethyl acetate extract was 20.7161 grams. Ethyl acetate extract of matoa leaves contains chemical compounds in the form of saponins, flavonoids and tannins. The total flavonoid content obtained from the ethyl acetate extract of matoa leaves was 6.19% and the IC 50 value was 34.21 ppm, while quercetin as a comparison had an IC 50 value of 4.75 ppm. Ethyl acetate extract of matoa (Pometia Pinnata) leaves has a total flavonoid content of 6.19% and very strong antioxidant activity, the same as quercetin as a comparison.]]>
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