<![CDATA[Diabetes mellitus is one of the metabolic disorders characterized by a progressive decrease in insulin sensitivity, resulting in hyperglycemia which causes oxidative stress and damage to liver function. Currently, anti-fibrogenic treatment options are still limited, This study aims to determine the effect of capsules containing a combination of snakehead fish extract (Channa striata), meniran (Phyllanthus niruri L.), and curcuma (Curcuma xantorrhiza) on a high fat diet of diabetic melitus model rats. This type of research is an experimental laboratory in vivo with a randomized post test-only control group design. The population of this study is male rats (Rattus norvegicus) of the wistar strain with a sample size of 30 mice divided into 5 groups of rats. Data analysis used the SPSS version 26 program which was analyzed by the Kruskal-Wallis and Mann-Whitney statistical tests. The results of this study found that there was a difference but not significant between SGOT and SGPT between all groups (p>0.05). Therefore, from these results, it can be stated that there is an effect of capsules containing a combination of snakehead fish extract (Channa striata), meniran (Phyllanthus niruri L.), and curcuma (Curcuma xantorrhiza) in diabetic mellitus model rats with a high fat diet in improving liver function. It is hoped that further researchers can continue this research by using a combination of snakehead fish extract (Channa striata), meniran (Phyllanthus niruri L.), and curcuma (Curcuma xantorrhiza) in repairing damage to other organs other than the liver as a result of diabetes mellitus complications.]]>
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