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The Effectiveness Test of Bangun-Bangun Leaves Extract (Plecthranthus Ambonicus) Against Streptococcus Pyogenes and Salmonella Typhi Bacteria Yulizal, Ok; Windi Anggriani; Stella Retta Marina; Ayu hasanah
Biomedical Journal of Indonesia Vol. 6 No. 3 (2020): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i3.240

Background Bangun-bangun leaves (Plectranthus amboinicus) are part of theLamiaceae family. (1) (1) Bangun-bangun leaves have a characteristic aromatic leavesaroma used as a medicinal plant (2). According to research conducted by (Dalimuntheet al., 2016) to find the use of this plant as an antibacterial because it containscompounds such as flavonoids, tannins, tripenoids, saponins, and essential oils. Onthe bangun-bangun leaves there is carvacrol, which is an essential component that hasantibacterial activity in positive or negative gram bacteria. streptococcus pyogenesbacteria are vectors of suppurative infectious diseases and other diseases such aspharyngitis. While salmonella typhi bacteria is a vector of the disease which is usuallycalled typhus and the medical language is typhoid fever. The purpose of this study wasto determine that the bacteria salmonella typhi and streptococcus pyogenens can beinhibited by the leaves extract. The benefit of this research is to increase publicunderstanding and knowledge in the use of bangun-bangun leaves. The method usedin this study is an experimental method and post test only controlled group design. Forthe concentration used, namely 5%, 10%, 15%, 20%, 25% and this strength test is doneby inserting the extract into a petri dish that has a bacterial culture. Data processinguses one-way ANOVA with the aim of comparing each variable. To see the extractagainst bacteria. The results showed that there were variations in the diameter of theinhibition zone formed by the concentration of the extract. And the most effectiveconcentration to inhibit streptococcus pyogenes bacteria was a concentration of 25%,the inhibition zone diameter was 19.5mm, while salmonella typhi bacteria had aconcentration of 25% and the inhibition zone diameter was 37.7m

SUATU STUDI LITERATUR: AKTIVITAS ANTIDIABETIC DARI KULIT JERUK (Citrus sp.) Maya Sari Mutia; Chrismis Novalinda Ginting; OK Yulizal
Jurnal Maternitas Kebidanan Vol. 6 No. 2 (2021): Jurnal Maternitas Kebidanan
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jumkep.v6i2.2054

Diabetes mellitus is a chronic metabolic disease, which is not able to secrete insulin in sufficient quantities or the body is unable to use insulin effectively so there is an excess glucose level and immediately suffer from some complications against the organs. Diabetes mellitus can be cured by herb utility which are thought to have compounds that has an antidiabetic effect. Therefore, this literature study discusses the antidiabetic activity of orange peel (Citrus sp.). The literature search was carried out on the Google Scholar search engine which used some keyword included antidiabetic, extract, orange peel, Citrus. In this literature study, there are inclusion and exclusion criteria for selecting journals as literature sources. The results of 12 literatures review that orange peel had antidiabetic activity by decrease blood glucose levels in some animal trials that had received an effective dose of orange peel extract in each of the reviewed studies. Hence, it can be concluded that various type of Citrus peels has antidiabetic effect.

GAMBARAN KLINIS DAN PENATALAKSANAAN GAGAL GINJAL KRONIK PASIEN RAWAT INAP DI RUMAH SAKIT ROYAL PRIMA MEDAN OK Yulizal
PRIMER (Prima Medical Journal) Vol. 5 No. 1 (2020): Edisi April
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/pmj.v3i1.1168

Gagal ginjal kronik (GGK) adalah suatu proses patofisiologi dengan etiologi yang beragam, mengakibatkan penurunan fungsi ginjal yang progresif dan pada umumnya berakhir dengan gagal ginjal. Selanjutnya gagal ginjal adalah suatu keadaan klinis yang ditandai dengan penurunan fungsi ginjal yang ireversibel pada suatu saat yang memerlukan terapi pengganti ginjal yang tetap seperti dialisis atau transplantasi ginjal. Untuk mengetahui gambaran kasus gagal ginjal kronik di Rumah Sakit Royal Prima Medan, telah dilakukan penelitian deskriptif retrospektif dengan desain studi kasus. Populasi seluruh data rekam medis pasien gagal ginjal kronik di Rumah Sakit Royal Prima Medan yang berjumlah 100. Besar sample yang dibutuhkan diambil secara purposive. Ditemukan umur termuda 17 tahun dan tertua 78 tahun, dan kelompok umur terbanyak >60 tahun 30%. Jenis kelamin terbanyak laki-laki 69%. Keluhan utama terbanyak mual 28%. Keluhan tambahan terbanyak edem perifer 38%. Pemeriksaan fisik tertinggi adalah peningkatan tekanan darah (hipertensi) 56%. Kadar ureum terbanyak > 100 mg/dl 79%. Kadar kreatinin terbanyak > 4 g/dl 100%. Kadar hemoglobin tertinggi >10g/dl 41%. Penatalaksanaan terbanyak hemodialisis 91%. Dalam melihat angka kejadian diatas sebaiknya diperlukan upaya pencegahan dengan mengubah pola hidup sehat dengan menjauhi faktor resiko pemicu munculnya berbagai penyakit yang dapat menyebabkan terjadinya penyakit gagal ginjal kronik.

Pengaruh Ekstrak Ikan Gabus (Channa striata) dan Metformin Terhadap Kontrol Glikemik Tikus Model Diabetes Melitus OK Yulizal; Ravinder Singh; Hendra Salim; Hendy Million
Jurnal Ilmiah Kesehatan Sandi Husada Vol 10 No 2 (2021): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v10i2.639

Introduction; Diabetes mellitus (DM) is still a major problem where people with DM today range from 463 million adults aged 20-79 years (9.3%). Cork fish (Channa striata) is one of the natural ingredients containing albumin that is reviewed to have antioxidant activity in beta-pancreatic cells so it is believed to treat DM. Snakehead fish has some efficacy including; has antinociceptive activity, accelerates wound healing, and is an anti-inflammatory. Objective; To determine the effect of snakehead fish extract and metformin on glycemic control of male rats with diabetes mellitus. Methods; This study used an experimental method with a post-test-only control group design. Results; Based on the Kruskal Walis test, it showed (p < 0.05) meaning that there was an effect of EIG administration on reducing blood glucose levels in rats, and there was a reduction of HbA1c but not significant. Conclusion; The combination of snakehead fish extract 300mg/kg BW and metformin 45 mg/kg BW was superior in lowering blood glucose and HbA1c levels compared to single therapy with snakehead fish extract or metformin.

The Effectiveness Test of Bangun-Bangun Leaves Extract (Plecthranthus Ambonicus) Against Streptococcus Pyogenes and Salmonella Typhi Bacteria Windi Anggriani; Stella Retta Marina; Ayu Hasanah; OK Yulizal
Biomedical Journal of Indonesia Vol. 6 No. 3 (2020): Vol 6, No 3, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i3.240

Background Bangun-bangun leaves (Plectranthus amboinicus) are part of theLamiaceae family. (1) (1) Bangun-bangun leaves have a characteristic aromatic leavesaroma used as a medicinal plant (2). According to research conducted by (Dalimunthe et al., 2016) to find the use of this plant as an antibacterial because it contains compounds such as flavonoids, tannins, tripenoids, saponins, and essential oils. On the bangun-bangun leaves there is carvacrol, which is an essential component that has antibacterial activity in positive or negative gram bacteria. streptococcus pyogenes bacteria are vectors of suppurative infectious diseases and other diseases such as pharyngitis. While salmonella typhi bacteria is a vector of the disease which is usually called typhus and the medical language is typhoid fever. The purpose of this study was to determine that the bacteria salmonella typhi and streptococcus pyogenens can be inhibited by the leaves extract. The benefit of this research is to increase public understanding and knowledge in the use of bangun-bangun leaves. The method used in this study is an experimental method and post test only controlled group design. For the concentration used, namely 5%, 10%, 15%, 20%, 25% and this strength test is done by inserting the extract into a petri dish that has a bacterial culture. Data processing uses one-way ANOVA with the aim of comparing each variable. To see the extract against bacteria. The results showed that there were variations in the diameter of the inhibition zone formed by the concentration of the extract. And the most effective concentration to inhibit streptococcus pyogenes bacteria was a concentration of 25%, the inhibition zone diameter was 19.5mm, while salmonella typhi bacteria had a concentration of 25% and the inhibition zone diameter was 37.7m.

DEPRESI PADA LANSIA PENDERITA DIABETES MELITUS TIPE 2 DI RUMAH SAKIT UMUM DAERAH DR. TENGKU MANSYUR TANJUNGBALAI TAHUN 2015 Nur Astari; OK Yulizal; Armon Rahimi; Herlina yani; Anita Rosari; Wika Hanida; Yensuari -
PRIMER (Prima Medical Journal) Vol. 7 No. 1 (2022): Edisi April
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/pmj.v7i1.2788

Hiperglikemik merupakan keadaan adanya defek pada sekresi atau kerja insulin yang dapat berakibat diabetes melitus. Diabetes yang berlangsung lama memungkinkan pasien mengalami depresi yang ditandai dengan mood tertekan, kehilangan kesenangan atau minat, perasaan bersalah atau harga diri rendah, gangguan makan atau tidur, kurang energi, dan konsentrasi yang rendah. Tujuan: Penelitian ini bertujuan untuk mengetahui ada atau tidaknya depresi pada penderita lansia dengan diabetes melitus tipe 2. Metode: Penelitian analitik dengan desain cross sectional study dan case control. Data diperoleh dengan menggunakan kuesioner yang dibagikan kepada lansia yang menderita DM dan non DM. Hasil: Subyek dalam penelitian ini berjumlah 176 orang lansia, terdiri dari 88 kelompok kasus (DM) dan 88 kelompok kontrol (non DM), didapatkan penderita DM yang paling banyak mengalami depresi berjenis kelamin laki-laki berjumlah 31 orang, non depresi terbanyak pada perempuan 22 orang. Mereka yang menderita DM 1,9 kali lebih beresiko untuk mengalami depresi dibanding non DM (OR = 1,9 (interval keyakinan 95%) 1,044 - 3,457, P = 0,036). Rerata lama penyakit pada subyek yang depresi antara DM dan non DM berbeda bermakna (5,51 ± 2,66 vs 3,54 ± 2,22, P = 0,000). Rerata KGD pada penderita DM yang depresi dibanding non depresi berbeda bermakna (310,31 ± 101,01 vs 262,89 ± 92,78, P = 0,029). Rerata lama penyakit untuk tingkatan depresi (ringan, sedang, berat) berbeda secara bermakna (3,00 ± 0,00 vs 4,97 ± 2,36 vs 7,06 ± 2,70, P = 0,000). Kesimpulan: Lansia penderita DM lebih beresiko mengalami depresi dibanding lansia non DM. Rerata lama penyakit pada subyek yang depresi antara DM dan non DM berbeda bermakna. Rerata KGD pada penderita DM yang depresi dibanding non depresi berbeda bermakna. Rerata lama penyakit untuk tingkatan depresi (ringan, sedang, berat) berbeda secara bermakna.

Activity Test of Squid Ink (Loligo Sp.) As Antibacterial Against Enterococcus Faecalis and Pseudomonas Aeruginosa Bacteria Valencia Angelina Halim; Sara Rai Faomasi Duha; OK Yulizal; Irza Haicha Pratama
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 3 (2023): August 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i3.168

Squid (Loligo sp.) is an invertebrate animal, part of the cephalopod class. The squid has a distinctive black ink fluid for self-defense. Squid ink contains melanin compounds that can be used as an antibacterial. Enterococcus faecalis is a bacterium that causes endodontic infection. While Pseudomonas aeruginosa is a bacterium that causes infection in patients with compromised immune system, and also who using a urinary catheter or intravenous catheter. This study aims to determine whether squid ink can be used as an antibacterial that can suppress the growth of Enterococcus faecalis and Pseudomonas aeruginosa bacteria. This research was conducted with experimental method, true experimental Post-Test Only Control Group research design. The research by using squid ink was carried out by inserting extract with various concentration (20%, 40%, 60%, 80% and 100%) into a petri dish which containing bacterial culture. The final showed that between concentrations of 20%, 40%, 60%, 80% and 100% were no clear zones, which had been repeated 3 times against Enterococcus faecalis and Pseudomonas aeruginosa bacteria. From the results obtained, it can be concluded that there is no bacterial inhibition caused by squid ink against Enterococcus faecalis and Pseudomonas aeruginosa.

Level Of Anxiety In Patients Undergoing Elective Gastroscopy With General And Local Anesthesia Audrey Yohan Agnes*; OK Yulizal; Yensuari Yensuari
Riwayat: Educational Journal of History and Humanities Vol 6, No 3 (2023): Social, Political, and Economic History
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jr.v6i3.34245

Gastrointestinal endoscopy involves the examination of the mucous membranes of the esophagus, stomach, and duodenum using an instrument equipped with a camera to provide visual images. This procedure has numerous clinical applications, including accurate diagnosis and effective guidance for upper gastrointestinal tract conditions. Insufficient patient knowledge about the impending procedure, potential procedural side effects, or anticipated examination outcomes can lead to heightened anxiety of the patient. This study aims to assess the level of anxiety in patients undergoing gastroscopy. An observational analytical study was conducted using a cross-sectional design, based on the Hamilton Anxiety Rating Scale (HARS) questionnaire. Moderate anxiety was found in 25 individuals (50%) among patients undergoing gastroscopy with local anesthesia. Meanwhile, among patients undergoing gastroscopy with general anesthesia, 15 individuals (30%) exhibited mild anxiety, and 5 individuals (10%) had moderate anxiety. There is a discernible difference in anxiety levels between patients undergoing elective gastroscopy with general anesthesia and those receiving local anesthesia.

Nephroprotective Effects of Sunkist Peel Ethanol Extract on Diabetic Nephropathy Mutia, Maya Sari; Ginting, Chrismis Novalinda; Yulizal, OK; Suhartomi, Suhartomi; Sihotang, Widya Yanti
Majalah Kedokteran Bandung Vol 56, No 3 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3496

The most common long-term diabetic complication is diabetic nephropathy which, in most cases, falls into the End-Stage Kidney Disease. Numerous studies on the nephroprotective effects of citrus fruit have been conducted recently. This study was performed to investigate the phytochemical properties of Sunkist peel ethanol extract and their possible effects on improving diabetic nephropathy. To get the extract, the Sunkist peels were macerated and the extract was analyzed by GC-MS. An in vivo assay of five different groups of 25 male Wistar rats was then performed using the extracts. The groups included control, standard, 500 mg/kg extract, 750 mg/kg extract, and 1,500 mg/kg BW extract. All rats were sacrificed after 28 days of treatment and VEGF level serum and kidney histology analysis were performed. The VEGF data were first analyzed descriptively, followed by one-way ANOVA or Kruskal-Wallis test based on the data distribution. Meanwhile, the kidney histology was observed and narratively described. Results showed that the Sunkist peel ethanol extract has a potential effect to suppress the VEGF level (p-value < 0.05). The extract at the highest dose revealed the mildest pathology damage in the form of tubular structure degeneration without any glomerular damage. This study indicates that Sunkist peel extract has nephroprotective effects from its various phytochemical compounds that work as antioxidants and anti-inflammation.

Pengaruh Ekstrak Ikan Gabus (Channa striata) dan Metformin Terhadap Kontrol Glikemik Tikus Model Diabetes Melitus OK Yulizal; Ravinder Singh; Hendra Salim; Hendy Million
Jurnal Ilmiah Kesehatan Sandi Husada Vol 10 No 2 (2021): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v10i2.639

Introduction; Diabetes mellitus (DM) is still a major problem where people with DM today range from 463 million adults aged 20-79 years (9.3%). Cork fish (Channa striata) is one of the natural ingredients containing albumin that is reviewed to have antioxidant activity in beta-pancreatic cells so it is believed to treat DM. Snakehead fish has some efficacy including; has antinociceptive activity, accelerates wound healing, and is an anti-inflammatory. Objective; To determine the effect of snakehead fish extract and metformin on glycemic control of male rats with diabetes mellitus. Methods; This study used an experimental method with a post-test-only control group design. Results; Based on the Kruskal Walis test, it showed (p < 0.05) meaning that there was an effect of EIG administration on reducing blood glucose levels in rats, and there was a reduction of HbA1c but not significant. Conclusion; The combination of snakehead fish extract 300mg/kg BW and metformin 45 mg/kg BW was superior in lowering blood glucose and HbA1c levels compared to single therapy with snakehead fish extract or metformin.

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