Exploring the Therapeutic Potential of Kalanchoe Pinnata: A Comprehensive Analysis of Bioactive Compounds and Pharmacological Activities

Bhusal, Dakshina
Poudel, Manila
Tamang, Ashika
Dhital, Sujan
Parajuli, Nirmal
Shrestha, Timila
Bharati, Samjhana
Maharjan, Binita
Adhikari Subin, Jhashanath
Marasini, Bishnu Prasad
Shrestha, Ram Lal Swagat

Biology, Medicine, & Natural Product Chemistry
Vol 13, No 2 (2024)

Natural products are vital in drug discovery for their bioactive compounds. This study evaluated Kalanchoe pinnata's leaf extracts for antidiabetic, antimicrobial, antioxidant, and cytotoxic properties. GC-MS identified seven components in hexane and twenty in methanol extracts. The ethyl acetate extract had high phenolic (485.17 mg GAE/g) and flavonoid (40.25 mg QE/g) contents. Methanol extract showed strong antioxidant (IC50: 293.53 µg/mL) and anti-alpha glucosidase (IC50: 195.39 µg/mL) activity. Antimicrobial tests showed varied effectiveness, while chloroform and acetone extracts exhibited notable cytotoxicity. ADMET predictions assessed absorption and blood-brain barrier penetration, highlighting K. pinnata's potential for drug development.